Enzyme-inspired flavin-polydopamine as a biocompatible nanoparticle photocatalyst
Enzyme-inspired flavin-polydopamine as a biocompatible nanoparticle photocatalyst
复制标题
DOI：
10.1039/c9nh00199a
复制
发表时间：
2019-11-01
影响因子：
9.7
通讯作者：
Fruk, Ljiljana
中科院分区：
文献类型：
--
作者：
Crocker, Leander;Koehler, Philipp;Fruk, Ljiljana
提出了一种旨在设计酶激发的光催化剂的新方法，该方法利用黄素的固有光催化活性和多巴胺的容易聚合来提供含混合辅因子的纳米颗粒。黄素-聚多巴胺系统受益于易于合成、在大小和活性方面的可调谐性以及对催化反应的优异的时间控制。这种新颖的，多功能的光催化剂表现出显色酶底物的光氧化和光还原。此外，所制备的混合纳米颗粒被证明是无毒的，为它们在绿色催化之外的更广泛的应用铺平了道路，例如各种治疗方法的抗氧化剂佐剂。
A new approach aimed at designing an enzyme-inspired photocatalyst is presented that exploits the inherent photocatalytic activity of flavin and the facile polymerization of dopamine to afford hybrid cofactor-containing nanoparticles. The flavin-polydopamine system benefits from ease of synthesis, tunability in terms of size and activity, and excellent temporal control over the catalyzed reactions. This novel, versatile photocatalyst exhibits both photooxidation and photoreduction of chromogenic enzymatic substrates. In addition, the prepared hybrid nanoparticles are shown to be non-toxic, paving the way to their use in a wider range of applications beyond green catalysis, such as antioxidant adjuvants to various therapeutic approaches.