Disrupted functional brain connectivity during verbal working memory in children and adolescents with schizophrenia.
Disrupted functional brain connectivity during verbal working memory in children and adolescents with schizophrenia.
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DOI：
10.1093/cercor/bhq114
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发表时间：
2011-03
期刊：
影响因子：
3.7
通讯作者：
T. White;Marcus Schmidt;D. Kim;V. Calhoun
中科院分区：
文献类型：
--
作者：
T. White;Marcus Schmidt;D. Kim;V. Calhoun
患有精神分裂症的儿童和青少年往往比患有这种疾病的成年人症状更严重。由于大脑持续成熟到成年早期，大脑结构和功能的发育差异可能为精神分裂症的潜在神经生物学提供线索。随着大量证据支持连接中断有助于精神分裂症的潜在病理生理学，我们的目标是评估儿童和青少年精神分裂症患者功能连接的差异。参与者共包括28名儿童和青少年（14名精神分裂症患者和14名年龄和性别匹配的对照组）。所有受试者都进行了功能性磁共振成像扫描，涉及修改后的斯滕贝格项目识别范式与3个工作记忆（WkM）负荷。患者在所有3 WkM负荷下的表现较差，无诊断相互作用的负荷。功能成像结果显示，儿童和青少年精神分裂症患者的3个特定脑网络被破坏。这些网络包括：1）两侧的前扣带回和颞叶; 2）小脑和皮质下区域; 3）枕叶和小脑。早发性精神分裂症患者在涉及边缘系统、颞叶、小脑和早期视觉处理流的网络中表现出异常的功能连接。
Children and adolescents who develop schizophrenia tend to have greater symptom severity than adults who develop the illness. Since the brain continues to mature into early adulthood, developmental differences in brain structure and function may provide clues to the underlying neurobiology of schizophrenia. With an emerging body of evidence supporting disrupted connectivity contributing to the underlying pathophysiology of schizophrenia, it was our goal to assess differences in functional connectivity in children and adolescents who develop schizophrenia. Participants included a total of 28 children and adolescents (14 patients with schizophrenia and 14 age- and gender-matched controls). All subjects underwent a functional magnetic resonance imaging scan involving a modified Sternberg Item Recognition Paradigm with 3 working memory (WkM) loads. Patients had poorer performance at all 3 WkM loads without a load by diagnosis interaction. Functional imaging results demonstrated 3 specific brain networks disrupted in children and adolescents with schizophrenia. These networks include 1) the anterior cingulate and the temporal lobes, bilaterally; 2) the cerebellum with subcortical regions; and 3) the occipital lobe and the cerebellum. Patients with early-onset schizophrenia demonstrate abnormal functional connectivity in networks involving limbic, temporal lobe, cerebellum, and early visual processing streams.