EFFECT OF IMPLANTATIONAL DELAY ON CELLULAR PROLIFERATION IN THE MOUSE BLASTOCYST
EFFECT OF IMPLANTATIONAL DELAY ON CELLULAR PROLIFERATION IN THE MOUSE BLASTOCYST
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DOI：
10.1530/jrf.0.0660681
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
COPP, AJ
中科院分区：
文献类型：
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作者：
COPP, AJ
在植入延迟的第10天，与植入前非延迟的囊胚相比，小鼠囊胚含有相对较多的壁滋养外胚层细胞，但内细胞团细胞相对较少。这些差异可能是由于长时间的极滋养外胚层细胞分裂加上极至壁细胞运动，以及延迟囊胚中内细胞团有丝分裂活性的减少。单次注射雌二醇后18小时开始着床，在此期间细胞数量或有丝分裂活性没有增加。延迟囊胚，无论是在雌二醇激活之前还是之后，都不是植入前非延迟囊胚的真正对应物。
On day 10 of implantational delay, mouse blastocysts contain relatively more mural trophectoderm cells, but relatively fewer inner cell mass cells, than do non-delayed blastocysts immediately before implantation. These differences are probably due to prolonged polar trophectodermal cell division plus polar-to-mural cell movement, and to reduce inner cell mass mitotic activity in delayed blastocysts. Implantation began 18 h after a single injection of estradiol, and there was no increase in cell numbers or mitotic activity in the intervening period. Delayed blastocysts, whether before or after activation by estradiol, are not true counterparts of non-delayed blastocysts immediately before implantation.