Frontal brain activation during the Wisconsin Card Sorting Test assessed with two-channel near-infrared spectroscopy
Frontal brain activation during the Wisconsin Card Sorting Test assessed with two-channel near-infrared spectroscopy
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DOI：
10.1007/s004060050045
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发表时间：
1998-10-01
影响因子：
4.7
通讯作者：
Strik, WK
中科院分区：
文献类型：
--
作者：
Fallgatter, AJ;Strik, WK
近红外光谱(NIRS)是一种新的非侵入性光学技术，适用于检测脑组织中氧合(O2Hb)和脱氧(HHb)血红蛋白的浓度变化。之前的近红外光谱研究表明，在不同的认知任务中，血液氧合变化的模式不同。尤其是在阅读过程中发现双侧额叶低氧，在连续操作测试中发现右侧额叶高氧，在言语流畅性测试中发现左侧额叶高氧。威斯康星卡片分类测试(WCST)是一种神经心理学测试，被认为主要激活额叶。病变研究和功能成像(单光子发射计算机断层扫描和正电子发射断层扫描)证明了这一点。在本研究中，应用双通道近红外光谱系统研究了10名健康受试者在进行WCST时的额叶脑区。与静息状态相比，WCST期间双侧无半球差异的额叶脑区的O2Hb显著增加。这一结果表明额叶的增强灌注与局部激活相一致。这一发现进一步证明，近红外光谱技术足够灵敏，可以检测生理性的血氧变化。此外，与以前的研究相比，发现了一种不同于在其他认知任务中观察到的激活模式。结论是，结果反映了当地对世界科学技术委员会具体任务需求的反应。
Near-infrared spectroscopy (NIRS) is a new non-invasive optical technique suitable to assess the concentration changes of oxygenated (O2HB) and deoxygenated (HHB) hemoglobin in brain tissue. Previous NIRS studies showed distinct patterns of blood oxygenation changes during different cognitive tasks. In particular, bilateral frontal hypo-oxygenation was found during reading, right frontal hyper-oxygenation during the Continuous Performance Test, and left frontal hyper-oxygenation during the Verbal Fluency Test. The Wisconsin Card Sorting Test (WCST) is a neuropsychological test which is presumed to activate prevalently the frontal lobes. This was demonstrated by lesion studies and functional imaging (single photon emission computed tomography and positron emission tomography). In the present study, a two-channel NIRS system was applied to investigate frontal brain areas of ten healthy subjects during performance of the WCST. A significant bilateral increase of O2HB in frontal brain regions without hemispheric differences was found during the WCST compared with a baseline at rest. This result indicates an enhanced perfusion of the frontal lobes consistent with local activation. The findings add further evidence that the NIRS technique is sensitive enough to detect physiological blood oxygenation changes. Furthermore, a comparison with previous studies revealed an activation pattern distinct from those observed during other cognitive tasks. It is concluded that the results reflect local responses to specific task demands of the WCST.