Neurocognitive outcomes in survivors of childhood cancer
Neurocognitive outcomes in survivors of childhood cancer
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DOI：
10.1093/jpepsy/jsi016
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发表时间：
2005-01-01
影响因子：
3.6
通讯作者：
Moore, BD
中科院分区：
文献类型：
--
作者：
Moore, BD
目的回顾与儿童癌症幸存者神经认知结果相关的问题。并对今后的研究方向提出了建议。方法回顾了大量关于癌症幸存者神经认知功能的文献。大脑发育和方法学问题，提供了挑战，进行有意义的研究，在癌症的结果也进行了讨论。结果某些癌症治疗中使用的神经毒性药物会产生永久性的神经认知后遗症，特别是在非常年幼的儿童中。结论儿童癌症幸存者的神经认知研究的状态需要超越神经认知后遗症的实证研究，研究将确定个体患者的神经认知发病率的风险。
Objectives To review issues associated with neurocognitive outcome in survivors of pediatric cancer. Recommendations are made for future research directions. Methods A large body of literature pertaining to neurocognitive outcome in cancer survivors was reviewed. Brain development and methodological issues that provide challenges to conducting meaningful research in cancer outcomes also are discussed. Results Neurotoxic agents used in some cancer therapies produce permanent neurocognitive sequelae, especially in very young children. Conclusions The state of neurocognitive research for pediatric cancer survivors needs to move beyond empirical studies of neurocognitive sequelae to research that will identify individual patients at risk for neurocognitive morbidity.