Spike-triggered averages for passive and resonant neurons receiving filtered excitatory and inhibitory synaptic drive
Spike-triggered averages for passive and resonant neurons receiving filtered excitatory and inhibitory synaptic drive
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DOI：
10.1103/physreve.78.011914
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发表时间：
2008-07-01
影响因子：
2.4
通讯作者：
Richardson, Magnus J. E.
中科院分区：
文献类型：
--
作者：
Badel, Laurent;Gerstner, Wulfram;Richardson, Magnus J. E.
本文提出了一种分析电压门控阈下电流神经元尖峰触发平均量的路径积分方法。使用线性化过程，以减少模型的广义积分和火灾的形式，解析表达式得到的波动驱动射击的实验相关的限制。电压门控通道以及兴奋性和抑制性突触过滤的影响显着影响神经元动力学之前的尖峰。分析形式给出了所有相关的生理量，如平均电压触发的尖峰，平均电流流经电压门控通道，和平均兴奋性和抑制性电导波形之前的尖峰。的数学结果被证明是在良好的协议与数值模拟的基础上的非线性电导为基础的模型。该方法有望提供一个有用的分析工具的预测和解释的时间结构的尖峰触发的平均实验测量。
A path-integral approach is developed for the analysis of spike-triggered average quantities in neurons with voltage-gated subthreshold currents. Using a linearization procedure to reduce the models to the generalized integrate-and-fire form, analytical expressions are obtained in an experimentally relevant limit of fluctuation-driven firing. The influences of voltage-gated channels as well as excitatory and inhibitory synaptic filtering are shown to affect significantly the neuronal dynamics prior to the spike. Analytical forms are given for all relevant physiological quantities, such as the mean voltage triggered to the spike, mean current flowing through voltage-gated channels, and the mean excitatory and inhibitory conductance waveforms prior to a spike. The mathematical results are shown to be in good agreement with numerical simulations of the underlying nonlinear conductance-based models. The method promises to provide a useful analytical tool for the prediction and interpretation of the temporal structure of spike-triggered averages measured experimentally.