Long non-coding RNAs in cancer progression.
Long non-coding RNAs in cancer progression.
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DOI：
10.3389/fgene.2012.00219
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发表时间：
2012
影响因子：
3.7
通讯作者：
Akimitsu N
中科院分区：
文献类型：
--
作者：
Tano K;Akimitsu N
最近的大规模转录组分析表明，转录分布在整个哺乳动物基因组中，产生大量的转录本，包括具有很少或没有蛋白质编码能力的长非编码RNA（lncRNA）。几十种lncRNA已被鉴定为具有生物学意义。在许多情况下，lncRNA在诸如染色质重塑、转录和转录后加工的过程的调节中充当关键分子。几种lncRNA（例如，MALAT1、HOTAIR和ANRIL）与包括癌症在内的人类疾病相关。与癌症相关的lncRNA通常异常表达。尽管lncRNA调节癌症发展的潜在分子机制尚不清楚，但最近的研究表明lncRNA的这种异常表达影响癌症的进展。在这篇综述中，我们强调了最近的研究结果，lncRNA在癌症生物学中的作用。
Recent large-scale transcriptome analyses have revealed that transcription is spread throughout the mammalian genomes, yielding large numbers of transcripts, including long non-coding RNAs (lncRNAs) with little or no protein-coding capacity. Dozens of lncRNAs have been identified as biologically significant. In many cases, lncRNAs act as key molecules in the regulation of processes such as chromatin remodeling, transcription, and post-transcriptional processing. Several lncRNAs (e.g., MALAT1, HOTAIR, and ANRIL) are associated with human diseases, including cancer. Those lncRNAs associated with cancer are often aberrantly expressed. Although the underlying molecular mechanisms by which lncRNAs regulate cancer development are unclear, recent studies have revealed that such aberrant expression of lncRNAs affects the progression of cancers. In this review, we highlight recent findings regarding the roles of lncRNAs in cancer biology.