Adjuvant effect of type I interferon induced by many but not all commercial influenza vaccines.
Adjuvant effect of type I interferon induced by many but not all commercial influenza vaccines.
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I型干扰素的辅助作用是由许多但并非所有商业流感疫苗引起的。
DOI：
10.1016/j.vaccine.2020.12.051
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发表时间：
2021-01-29
期刊：
影响因子：
5.5
通讯作者：
Canaday DH
中科院分区：
文献类型：
--
作者：
Damjanovska S;Smith C;Sayin I;Burant CJ;Gravenstein S;Canaday DH
在美国批准和提供的季节性流感疫苗每年都有不同程度的有效报告，不同的制造商之间也有不同程度的有效。由活病毒生产的流感疫苗可能包括单链RNA(SsRNA)，它是天然Toll样受体7(TLR-7)配体的有效激活剂。单链RNA能激活浆细胞样树突状细胞产生干扰素-α等I型干扰素，具有佐剂样效应。我们的目的是确定8种不同的商业流感疫苗对外周血单个核细胞(PBMC)的干扰素-α诱导是否是通过TLR-7信号介导的依赖于PDC的过程。我们展示了多种疫苗以依赖于TLR7的方式诱导干扰素-α的能力。然而，许多疫苗缺乏干扰素-α的诱导。疫苗之间的这些差异的意义尚不清楚，因为所有经批准的疫苗配方都提供了一定程度的保护。
Seasonal influenza vaccines approved and offered in the United States have varying reported degrees of effectiveness year over year and between manufacturers. Influenza vaccines produced from live virus may include single stranded RNA (ssRNA) that is a potent activator of the innate Toll-like receptor 7 (TLR-7) ligand. Plasmacytoid dendritic cells (pDC) can be activated by ssRNA to produce type I interferons such as IFN-α, which has been shown to have an adjuvant-like effect. Our aim was to determine if IFN-α induction in peripheral blood mononuclear cells (PBMCs) exposed to eight different commercial influenza vaccines is a pDC-dependent process mediated through TLR-7 signaling. We demonstrate the ability of multiple vaccines to induce IFN-α in a TLR-7-dependent fashion. A number of vaccines however lacked IFN-α induction. The significance of these differences between vaccines is unclear, since all the approved vaccine formulations offer some degree of protection.
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老年人的Fluad®-MF59®辅助流感疫苗。
影响因子：
4.2
作者：
Tsai TF
通讯作者：
Tsai TF
DOI：
10.1073/pnas.1319784110
发表时间：
2013-12-24
影响因子：
11.1
作者：
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通讯作者：
Seubert, Anja
影响因子：
5.5
作者：
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通讯作者：
Podda, A
影响因子：
158.5
作者：
DiazGranados, Carlos A.;Dunning, Andrew J.;Talbot, H. Keipp
通讯作者：
Talbot, H. Keipp
影响因子：
3.5
作者：
Rizza, Paola;Moretti, Franca;Belardelli, Filippo
通讯作者：
Belardelli, Filippo