ASK1 signalling regulates brown and beige adipocyte function.
ASK1 signalling regulates brown and beige adipocyte function.
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DOI：
10.1038/ncomms11158
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发表时间：
2016-04-05
影响因子：
16.6
通讯作者：
Ichijo H
中科院分区：
文献类型：
--
作者：
Hattori K;Naguro I;Okabe K;Funatsu T;Furutani S;Takeda K;Ichijo H
最近的研究表明，成年人具有活跃的棕色或米色脂肪细胞，其活化可能是治疗多种代谢疾病的治疗策略。在这里，我们表明，蛋白激酶ASK 1调节棕色和米色脂肪细胞的功能。在棕色或白色脂肪细胞中，PKA-ASK 1-p38轴响应cAMP信号而被激活，并有助于细胞自主诱导基因，包括Ucp 1。整体和脂肪特异性ASK1缺乏导致代谢反应受损，包括产热和耗氧，分别在细胞和全身水平。因此，我们的数据表明，ASK1信号轴是棕色和米色脂肪细胞基因表达和功能的调节因子。 蛋白激酶ASK1与细胞应激反应有关。在这里，作者表明ASK1还调节米色和棕色脂肪细胞的基因表达和活性，并证明脂肪细胞ASK1在调节小鼠产热中具有生理作用。
Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function. The protein kinase ASK1 has been linked to cellular stress responses. Here the authors show that ASK1 also regulates gene expression and activity of beige and brown adipocytes, and demonstrate adipocyte ASK1 has a physiological role in regulating thermogenesis in mice.