Disease drivers of aging.
Disease drivers of aging.
复制标题
DOI：
10.1111/nyas.13299
复制
发表时间：
2016-12
影响因子：
5.2
通讯作者：
Hunt PW
中科院分区：
文献类型：
--
作者：
Hodes RJ;Sierra F;Austad SN;Epel E;Neigh GN;Erlandson KM;Schafer MJ;LeBrasseur NK;Wiley C;Campisi J;Sehl ME;Scalia R;Eguchi S;Kasinath BS;Halter JB;Cohen HJ;Demark-Wahnefried W;Ahles TA;Barzilai N;Hurria A;Hunt PW
人们早就知道，在细胞和组织水平上，衰老有助于许多慢性疾病的病理发展和进展。然而，很少有研究考察了这种反比关系——慢性病及其治疗对衰老相关表型进展的贡献。在此，我们讨论了三种慢性疾病（癌症、艾滋病毒/艾滋病和糖尿病）及其治疗对衰老的影响，这些影响的可能介导机制，以及了解这些疾病与衰老之间关系所需的开放性问题和未来的研究方向。
It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship—the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.