Cigarette smoking and colorectal carcinoma mortality in a cohort with long-term follow-up
Cigarette smoking and colorectal carcinoma mortality in a cohort with long-term follow-up
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DOI：
10.1002/cncr.11923
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发表时间：
2004-01-15
期刊：
影响因子：
6.2
通讯作者：
Dyer, AR
中科院分区：
文献类型：
--
作者：
Colangelo, LA;Gapstur, SM;Dyer, AR
背景。有证据表明结直肠癌（CRC）可能是一种与烟草相关的恶性肿瘤。方法。在当前的研究中，作者在芝加哥心脏协会行业检测项目研究中检验了吸烟与结直肠癌死亡率之间的关联，该研究对 39,299 名男性和女性进行了队列研究，平均随访时间为 26 年。为了评估这种关联在可能有长期吸烟史的参与者中是否更强，作者还使用大于或等于 50 岁与 < 50 岁的基线年龄对分析进行分层。 结果。使用多变量 Cox 回归分析，男性和女性吸烟与结直肠癌死亡率之间存在边际显着趋势 (P = 0.06)。在老年参与者组的年龄分层分析中，男性、女性或男性和女性的组合没有明显的关联。在年轻参与者组中，吸烟与结直肠癌死亡率之间似乎存在女性以及男性和女性的剂量反应关系（趋势 P 值分别 = 0.008 和 0.03）。与从不吸烟者相比，每天吸烟超过 20 支的女性的相对风险为 2.49（95% 置信区间 [95% CI]，0.87-7.12），男性和女性合计的相对风险为 1.87（95% CI，1.08-3.22）。结论。目前的研究结果支持吸烟与结直肠癌死亡率之间的关联，特别是对于年龄 < 50 岁的女性。 (C) 2003 年美国癌症协会。
BACKGROUND. Evidence suggests that colorectal carcinoma (CRC) may be a tobacco-associated malignancy.METHODS. In the current study, the authors examined the association between cigarette smoking and CRC mortality in the Chicago Heart Association Detection Project in Industry study, a cohort of 39,299 men and women with an average of 26 years of follow-up. To assess whether the association was stronger in participants with a potentially long history of smoking, the authors also stratified the analysis using a baseline age greater than or equal to 50 years versus < 50 years.RESULTS. Using multivariate Cox regression analysis, there was a marginally significant trend (P = 0.06) for men and women combined between smoking and CRC mortality. In the age-stratified analysis in the older participant group, there was no apparent association for men, women, or men and women combined. In the younger participant group, there appeared to be dose-response relations for women and for men and women combined (P value for trend = 0.008 and 0.03, respectively) between smoking and CRC mortality. The relative risk for women who smoked >20 cigarettes/day compared with never smokers was 2.49 (95% confidence interval [95% CI], 0.87-7.12), and was 1.87 for men and women combined (95% Cl, 1.08-3.22).CONCLUSIONS. The results of the current study support an association between cigarette smoking and CRC mortality, particularly in women age < 50 years. (C) 2003 American Cancer Society.