Dietary factors and incident atrial fibrillation: the Framingham Heart Study
Dietary factors and incident atrial fibrillation: the Framingham Heart Study
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DOI：
10.3945/ajcn.110.001305
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发表时间：
2011-02-01
影响因子：
7.1
通讯作者：
Benjamin, Emelia J.
中科院分区：
文献类型：
--
作者：
Shen, Jian;Johnson, Victor M.;Benjamin, Emelia J.
背景资料：饮食因素与心房颤动（AF）之间的关系一直存在矛盾的报道。目的：我们在心脏病研究中评估了酒精、咖啡因、纤维和多不饱和脂肪酸（PUFA）的摄入与AF之间的关系。设计：无AF的参与者（n = 4526; 9640次检查;平均年龄：62岁; 56%为女性）完成食物频率问卷，并前瞻性随访4年。我们用考克斯比例风险回归分析研究了饮食暴露与AF之间的关系。结果：共有296人发生AF（177名男性，119名女性）。在多变量分析中，检查的饮食暴露与AF风险之间没有显著相关性。饮食因素增加四分位数的风险比（HR）如下：对于酒精，0.73（95% CI：0.5，1.05），0.85（95% CI：0.61，1.18）和1.12（95% CI：0.83，1.51）（趋势P = 0.48）;咖啡因P = 0.84（95% CI：0.62，1.15），0.87（95% CI：0.64，1.2）和0.98（95% CI：0.7，1.39）（趋势P = 0.84）;总纤维为0.86（95% CI：0.61，1.2），0.64（95% CI：0.44，0.92）和0.81（95% CI：0.54，1.2）（趋势P = 0.16）;对于n-3（omega-3）PUFA，1.11（95% CI：0.81，1.54）、0.92（95% CI：0.65，1.29）和1.18（95% CI：0.85，1.64）（趋势P = 0.57;四分位数1为参考组）。在探索性分析中，每周食用>4份黑鱼与每周食用1份黑鱼相比，（HR：6.53; 95% CI：2.65，16.06; P < 0.0001）。酒精、咖啡因、纤维和鱼源性PUFA的摄入与AF风险无显著相关性。所观察到的食用黑鱼和AF之间的不良关联值得进一步研究。我们的研究结果表明，在一般人群中，所检查的饮食暴露传达了有限的AF归因风险。美国临床营养杂志2011;93：261-6.
Background: There have been conflicting reported associations between dietary factors and incident atrial fibrillation (AF).Objective: We evaluated associations between consumption of alcohol, caffeine, fiber, and polyunsaturated fatty acids (PUFAs) and incident AF in the Framingham Heart Study.Design: Participants without AF (n = 4526; 9640 examinations; mean age: 62 y; 56% women) from the original and offspring cohorts completed food-frequency questionnaires and were followed prospectively for 4 y. We examined the associations between dietary exposures and AF with Cox proportional hazards regression.Results: A total of 296 individuals developed AF (177 men, 119 women). In multivariable analyses, there were no significant associations between examined dietary exposures and AF risk. Hazard ratios (HRs) for increasing quartiles of dietary factors were as follows: for alcohol, 0.73 (95% CI: 0.5, 1.05), 0.85 (95% CI: 0.61, 1.18), and 1.12 (95% CI: 0.83, 1.51) (P for trend = 0.48); for caffeine, 0.84 (95% CI: 0.62, 1.15), 0.87 (95% CI: 0.64, 1.2), and 0.98 (95% CI: 0.7, 1.39) (P for trend = 0.84); for total fiber, 0.86 (95% CI: 0.61, 1.2), 0.64 (95% CI: 0.44, 0.92), and 0.81 (95% CI: 0.54, 1.2) (P for trend = 0.16); and for n-3 (omega-3) PUFAs, 1.11 (95% CI: 0.81, 1.54), 0.92 (95% CI: 0.65, 1.29), and 1.18 (95% CI: 0.85, 1.64) (P for trend = 0.57; quartile 1 was the reference group). In exploratory analyses, consumption of >4 servings of dark fish/wk (5 cases and 21 individuals at risk) was significantly associated with AF risk compared with the consumption of,1 serving of dark fish/wk (HR: 6.53; 95% CI: 2.65, 16.06; P < 0.0001).Conclusions: Consumption of alcohol, caffeine, fiber, and fish-derived PUFAs was not significantly associated with AF risk. The observed adverse association between the consumption of dark fish and AF merits further investigation. Our findings suggest that the dietary exposures examined convey limited attributable risk of AF in the general population. Am J Clin Nutr 2011;93:261-6.