Maternal stress differently alters nociceptive behaviors in the formalin test in adult female and male rats
Maternal stress differently alters nociceptive behaviors in the formalin test in adult female and male rats
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在成年雌性和雄性大鼠的福尔马林测试中，母体压力不同地改变伤害感受行为
DOI：
10.1016/s0006-8993(02)03833-7
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发表时间：
2003
期刊：
影响因子：
2.9
通讯作者：
E. Vershinina
中科院分区：
文献类型：
--
作者：
I. Butkevich;E. Vershinina
采用福尔马林试验研究妊娠最后一周Wistar大鼠约束应激对90 d雌、雄性后代特异性双相伤害性行为反应急性期和紧张期的长期影响。产前应激对福尔马林引起的疼痛产生了显著的变化，这在女性中比在男性中更为明显。雌性的扭曲反应更多地发生在椎骨上水平，在两个阶段，随着舔舐反应强度的增加以及持续时间的增加。有关间期长度变化的结果表明中枢神经系统的抑制机制受损。此外，产前应激对第一阶段的影响存在巨大差异，但对第二阶段的影响在女性和男性中具有相似性，这间接有力地支持了福尔马林试验中的第二阶段不能仅由中枢致敏介导，而在很大程度上取决于来自伤害性初级传入的信号。最后，在男性中获得的结果是支持急性和强直性疼痛不同机制假设的重要论据。综上所述，这些研究表明，在90天的福尔马林测试中，产前压力以性别特异性的方式改变了大鼠的伤害性行为。
The long-term effects of restraint stress in Wistar rats during the last week of gestation were investigated on the acute and tonic phases of the specific biphasic nociceptive behavioral response in the formalin test in offspring, females and males, at 90 days. Prenatal stress produced significant changes in formalin-induced pain, which was more pronounced in females as compared to males. The distorted response in females was more at the supraspinal level with an increased intensity of the licking response in both phases as well as with an increased their duration. Results concerning changes of the interphase length indicate the impairments of inhibitory mechanisms in the central nervous system. Furthermore, profound difference in the effects of prenatal stress on the first phase but similarity in these effects on the second phase in females and males are indirect strong support of the view that the second phase in the formalin test can not be mediated by central sensitization alone but greatly depends on signals ongoing from nociceptive primary afferents. Finally, the results obtained in males are important argument in favor of assumption about different mechanisms of acute and tonic pain. Taken together, these studies show that prenatal stress alters nociceptive behaviors in the formalin test in rats at 90 days in a sex-specific manner.
清醒大鼠中垂体-肾上腺皮质对持续伤害性刺激的反应：内源性皮质酮不会减少福尔马林试验中的伤害感受。
DOI：
10.1210/endo.139.5.5993
发表时间：
1998
期刊：
Endocrinology.
影响因子：
--
作者：
Taylor,BK;Akana,SF;Peterson,MA;Dallman,MF;Basbaum,AI
通讯作者：
Basbaum,AI
DOI：
10.1073/pnas.96.14.7739
发表时间：
1999-07-06
影响因子：
11.1
作者：
Basbaum, AI
通讯作者：
Basbaum, AI