Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness.
Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness.
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DOI：
10.1007/s13312-020-1997-1
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发表时间：
2020-10-15
影响因子：
2.3
通讯作者：
Ramanan AV
中科院分区：
文献类型：
--
作者：
Bhat CS;Gupta L;Balasubramanian S;Singh S;Ramanan AV
COVID-19大流行最初似乎仅导致儿童轻度疾病。然而，现在很明显，一小部分儿童可以发展出一种被称为小儿炎性多系统综合征的炎症综合征-与SARS-CoV-2（PIMS-TS）暂时相关。这种新发现的疾病的特征可能包括持续发热，炎症证据，以及在没有其他已知感染的情况下的单一或多器官功能障碍。其中一些儿童可能具有川崎病、中毒性休克综合征或细胞因子风暴综合征的特征。他们可能会迅速恶化，也可能需要重症监护支持。PCR检测通常为阴性;尽管大多数儿童都有SARS-CoV-2抗体。虽然发病机制尚不清楚，但免疫介导的损伤已被牵连。我们在此提供有关这种情况的最新信息，以提高儿科医生的认识。
The pandemic of COVID-19 initially appeared to cause only a mild illness in children. However, it is now apparent that a small percentage of children can develop a hyperinflammatory syndrome labeled as Pediatric inflammatory multisystem syndrome — temporally associated with SARS-CoV-2 (PIMS-TS). Features of this newly recognized condition may include persistent fever, evidence of inflammation, and single or multi-organ dysfunction in the absence of other known infections. Some of these children may share features of Kawasaki disease, toxic shock syndrome or cytokine storm syndrome. They can deteriorate rapidly and may need intensive care support as well. The PCR test is more often negative; although, most of the children have antibodies to SARS-CoV-2. Although the pathogenesis is not clearly known, immune-mediated injury has been implicated. We herein provide current information on this condition, in order to raise awareness amongst pediatricians.
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影响因子：
4.4
作者：
Burns JC;Franco A
通讯作者：
Franco A
影响因子：
4.3
作者：
SHEN, L;FANGER, MW
通讯作者：
FANGER, MW
DOI：
10.1016/j.berh.2014.03.002
发表时间：
2014-04
期刊：
Best practice & research. Clinical rheumatology
影响因子：
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作者：
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通讯作者：
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影响因子：
10.5
作者：
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通讯作者：
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影响因子：
37.8
作者：
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通讯作者：
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