Scratching movements evoked by drugs applied to the upper cervical cord
Scratching movements evoked by drugs applied to the upper cervical cord
复制标题
上颈髓涂抹药物引起的抓挠动作
DOI：
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发表时间：
1960
期刊：
影响因子：
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通讯作者：
K. Fleischhauer
中科院分区：
文献类型：
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作者：
W. Feldberg;K. Fleischhauer
下面的实验描述了搔抓引起的运动，不是反射性的，而是由局部应用于上颈髓的药物作用引起的。该实验是对戊巴比妥钠麻醉的猫进行偶然观察的结果，其中溴酚蓝染料通过脑室灌注，并研究其对脑组织的渗透（Feldberg & Fleischhauer, 1960）。在这些实验中，灌注是从有管的侧脑室到有管的导水管，只要染料不进入蛛网膜下腔，就没有观察到中枢效应。然而，在少数实验中，染料泄漏到蛛网膜下腔，或沿着输水导管的外侧，或由于第三脑室后部的薄顶破裂，后腿发生强烈的肌阵挛运动。当染料从侧脑室灌注到池中时，它们有规律地产生。这些发现表明，溴酚蓝存在于蛛网膜下腔时具有中枢兴奋作用，而通过脑室或导水管时则没有。当试图通过局部应用溴酚蓝在大脑、小脑、脑干和脊髓的不同部位定位作用部位时，发现肌阵挛运动只能从上颈髓背表面的有限区域引起，并且它们显示出与正常抓挠反射惊人的相似。此外，用管曲碱在同一区域也获得了类似的划痕运动，众所周知，管曲碱从侧脑室灌注到输水管时也会产生肌肉效应，即不进入蛛网膜下腔（Feldberg & Malcolm, 1959）。
The following experiments give a description of scratching movements elicited, not reflexly, but by the action of drugs when applied topically to the upper cervical cord. The experiments are the outcome of an incidental observation made in cats anaesthetized with pentobarbitone sodium, in which the dye bromophenol blue was perfused through the cerebral ventricles, and its penetration into the brain tissue was studied (Feldberg & Fleischhauer, 1960). In these experiments perfusion was effected from a cannulated lateral ventricle to the cannulated aqueduct, and as long as the dye did not enter the subarachnoid space no central effects were observed. However, in a few experiments in which the dye leaked out into the subarachnoid space, either along the outside of the aqueductal cannula or because of rupture of the thin roof of the posterior part of the third ventricle, strong myoclonic movements of the hind legs occurred. They were regularly produced when the dye was perfused from the lateral ventricle to the cisterna. These findings suggested that bromophenol blue had a central excitatory action when present in the subarachnoid space but not when passing through the cerebral ventricles or the aqueduct. When trying to locate the site of action of bromophenol blue by topical application to different parts of the cerebrum, cerebellum, brain stem and spinal cord, it was found that the myoclonic movements could be elicited only from a restricted area of the dorsal surface of the upper cervical cord and that they showed a striking resemblance to those of a normal scratch reflex. Further, similar scratching movements were obtained from the same area with tubocurarine, which is known to produce muscular effects also when perfused from the lateral ventricle to the aqueduct, that is, without passing into the subarachnoid space (Feldberg & Malcolm, 1959).