LONG-TERM FOLLOW-UP OF A CHOP-BASED REGIMEN WITH MAINTENANCE THERAPY AND CENTRAL-NERVOUS-SYSTEM PROPHYLAXIS IN LYMPHOBLASTIC NON-HODGKINS-LYMPHOMA
LONG-TERM FOLLOW-UP OF A CHOP-BASED REGIMEN WITH MAINTENANCE THERAPY AND CENTRAL-NERVOUS-SYSTEM PROPHYLAXIS IN LYMPHOBLASTIC NON-HODGKINS-LYMPHOMA
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DOI：
10.3109/10428199409049726
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发表时间：
1994-10-01
影响因子：
2.6
通讯作者：
GLICK, JH
中科院分区：
文献类型：
--
作者：
COLGAN, JP;ANDERSEN, J;GLICK, JH
东方合作肿瘤学小组(ECOG)在成人淋巴母细胞性非霍奇金淋巴瘤患者中进行了一项II期试验。采用环磷酰胺、阿霉素、长春新碱、强的松(CHOP)/L-天冬酰胺酶联合诱导方案治疗39例无中枢神经系统受累的患者，并给予鞘内注射甲氨蝶呤6次，12次24Gy面中部头颅放疗。31例患者(79%)获得完全缓解(CR)。在31例CRS患者中，12例复发(39%)。3例出现中枢神经系统复发。所有进入CR的患者都接受了维持性CHOP、阿糖胞苷(Ara-C)和甲氨蝶呤的治疗，然后再用Ara-C和甲氨蝶呤治疗。在诱导期和维持期分别有69%和70%的患者出现危及生命的白细胞减少或血小板减少。39例患者中有19例(49%)仍在CR中，随访9年。骨髓受累与生存率显著降低相关(P=0.03)。
The Eastern Cooperative Oncology Group (ECOG) conducted a phase II trial in adult patients with lymphoblastic non-Hodgkin's lymphoma. Thirty-nine patients with no central nervous system (CNS) involvement were treated with an induction cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP)/L-asparaginase regimen and CNS prophylaxis that included intrathecally administered methotrexate given 6 times and 24 Gy midplane cranial radiation in 12 fractions. Thirty-one patients (79%) achieved a complete remission (CR). Of the 31 patients with CRs, 12 relapsed (39%). CNS relapse occurred in three patients. All patients who entered a CR were treated with maintenance CHOP, cytosine arabinoside (Ara-C), and methotrexate and subsequently with Ara-C and methotrexate. Life-threatening leukopenia or thrombocytopenia was experienced in 69% of patients in the induction phase and in 70% in the maintenance phase. Nineteen of 39 patients (49%) remain in CR with a followup to 9 years. Bone marrow involvement was associated with a significantly worse survival (P = 0.03).