Overview of peroxiredoxins in oxidant defense and redox regulation.
Overview of peroxiredoxins in oxidant defense and redox regulation.
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DOI：
10.1002/0471140856.tx0709s49
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Nelson, Kimberly J
中科院分区：
文献类型：
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作者：
Poole, Leslie B;Hall, Andrea;Nelson, Kimberly J
过氧化氢还蛋白是一种重要的过氧化氢解毒酶，但相对于其他主要的过氧化氢解毒酶，含血红素的过氧化氢酶和过氧化物酶，以及谷胱甘肽过氧化物酶，过氧化还蛋白是近年来才出现的。这些半胱氨酸依赖的过氧化物酶与过氧化氢、有机过氧化氢和过氧亚硝酸盐具有很高的反应活性，不仅在过氧化防御中发挥重要作用，而且在调节过氧化介导的细胞信号转导中发挥重要作用。本文综述了过去几十年中出现的重要的过氧化还蛋白特征，重点介绍了其催化机制、调控和生物功能。
Peroxiredoxins are important hydroperoxide detoxification enzymes, yet have only come to the fore in recent years relative to the other major players in peroxide detoxification, heme-containing catalases and peroxidases, and glutathione peroxidases. These cysteine-dependent peroxidases exhibit high reactivity with hydrogen peroxide, organic hydroperoxides and peroxynitrite and play major roles not only in peroxide defense, but also in regulating peroxide-mediated cell signaling. This overview focuses on important peroxiredoxin features that have emerged over the past several decades with an emphasis on catalytic mechanism, regulation and biological function.