Full-thickness macular hole after intravitreal injection of ranibizumab in a patient with retinal pigment epithelium detachment and tear
Full-thickness macular hole after intravitreal injection of ranibizumab in a patient with retinal pigment epithelium detachment and tear
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DOI：
10.1177/112067211002000235
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发表时间：
2010-03-01
影响因子：
1.7
通讯作者：
Theodossiadis, Panagiotis
中科院分区：
文献类型：
--
作者：
Grigoropoulos, Vlassis;Emfietzoglou, John;Theodossiadis, Panagiotis
目的.目的：报道1例视网膜色素上皮脱离（PED）伴撕裂患者玻璃体内注射雷珠单抗后发生全层黄斑裂孔（FTMH）的病例。通过生物显微镜、荧光素和吲哚菁绿绿色血管造影以及光学相干断层扫描对一名67岁女性因年龄相关性黄斑变性而患有PED和视网膜色素上皮（RPE）撕裂进行了研究，并接受了玻璃体内雷珠单抗治疗。结果。该患者在雷珠单抗注射后1个月发生FTMH。玻璃体内雷珠单抗可在视网膜表面上产生牵引力的焦点部位，而脉络膜新生血管膜的收缩也可在RPE和外视网膜上施加力。这两种作用都可能导致视网膜的收缩和撕裂，导致FTMH的形成。(Eur J Ophthalmol 2010; 20：469-72）
PURPOSE. To report a case of full-thickness macular hole (FTMH) after intravitreal injection of ranibizumab in a patient with retinal pigment epithelium detachment (PED) and tear.METHODS. A 67-year-old woman with PED and retinal pigment epithelium (RPE) tear due to age-related macular degeneration was studied by biomicroscopy, fluorescein and indocyanine green angiography, and optical coherence tomography and was treated with intravitreal ranibizumab.RESULTS. The patient developed a FTMH that was observed 1 month after the ranibizumab injection.CONCLUSIONS. Intravitreal ranibizumab may create focal sites of tractional forces on the retinal surface while contraction of the choroidal neovascular membrane may also place forces on the RPE and outer retina. Both actions may have as a result contraction and tearing of the retina leading to the formation of a FTMH. (Eur J Ophthalmol 2010; 20: 469-72)