Epigenetic regulation in the inner ear and its potential roles in development, protection, and regeneration.
Epigenetic regulation in the inner ear and its potential roles in development, protection, and regeneration.
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DOI：
10.3389/fncel.2014.00446
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发表时间：
2014
影响因子：
5.3
通讯作者：
Zuo J
中科院分区：
文献类型：
--
作者：
Layman WS;Zuo J
新兴的表观遗传学领域开始对我们对组织发育、维持和功能的理解产生重大影响。表观遗传机制调节基因组的结构和活性，以响应细胞内和环境线索，指导细胞类型特异性基因网络。内耳由高度特化的细胞类型组成，这些细胞类型具有相同的基因组，起源于单个全能合子。在内耳发育过程中，转录因子和表观遗传修饰因子的特定组合必须以协调的方式发挥作用，以建立和维持细胞身份。这些表观遗传调控机制有助于维持不同的染色质状态和细胞类型特异性基因表达模式。在这篇综述中，我们强调了与内耳发育相关的表观遗传修饰的新兴范例，以及表观遗传学如何在听力损失，保护和再生中发挥重要作用。
The burgeoning field of epigenetics is beginning to make a significant impact on our understanding of tissue development, maintenance, and function. Epigenetic mechanisms regulate the structure and activity of the genome in response to intracellular and environmental cues that direct cell-type specific gene networks. The inner ear is comprised of highly specialized cell types with identical genomes that originate from a single totipotent zygote. During inner ear development specific combinations of transcription factors and epigenetic modifiers must function in a coordinated manner to establish and maintain cellular identity. These epigenetic regulatory mechanisms contribute to the maintenance of distinct chromatin states and cell-type specific gene expression patterns. In this review, we highlight emerging paradigms for epigenetic modifications related to inner ear development, and how epigenetics may have a significant role in hearing loss, protection, and regeneration.
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影响因子：
64.5
作者：
Hanna JH;Saha K;Jaenisch R
通讯作者：
Jaenisch R
影响因子：
3.7
作者：
Elkan-Miller T;Ulitsky I;Hertzano R;Rudnicki A;Dror AA;Lenz DR;Elkon R;Irmler M;Beckers J;Shamir R;Avraham KB
通讯作者：
Avraham KB
影响因子：
14.9
作者：
Calvanese V;Fernández AF;Urdinguio RG;Suárez-Alvarez B;Mangas C;Pérez-García V;Bueno C;Montes R;Ramos-Mejía V;Martínez-Camblor P;Ferrero C;Assenov Y;Bock C;Menendez P;Carrera AC;Lopez-Larrea C;Fraga MF
通讯作者：
Fraga MF
影响因子：
9.8
作者：
Bossuyt W;Kazanjian A;De Geest N;Van Kelst S;De Hertogh G;Geboes K;Boivin GP;Luciani J;Fuks F;Chuah M;VandenDriessche T;Marynen P;Cools J;Shroyer NF;Hassan BA
通讯作者：
Hassan BA
影响因子：
64.8
作者：
Gubbels, Samuel P.;Woessner, David W.;Mitchell, John C.;Ricci, Anthony J.;Brigande, John V.
通讯作者：
Brigande, John V.