X4-tropic Latent HIV-1 is Enriched in Peripheral Follicular Helper T Cells and is Correlated with Disease Progression.
X4-tropic Latent HIV-1 is Enriched in Peripheral Follicular Helper T Cells and is Correlated with Disease Progression.
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X4 向性潜伏 HIV-1 富含外周滤泡辅助 T 细胞，并且与疾病进展相关。
DOI：
10.1128/jvi.01219-19
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发表时间：
2020
影响因子：
5.4
通讯作者：
Deng Kai
中科院分区：
文献类型：
--
作者：
Yu Fei;Li Qijuan;Chen Xi;Liu Jun;Li Linghua;Li Baojin;Liu Bingfeng;Zhang Junsong;Zhang Xu;Liu Zhaoli;Luo Haihua;Tang Xiao Ping;Cai Weiping;Zhang Hui;Deng Kai
滤泡辅助 T (TFH) 细胞已被证明可以支持人类免疫缺陷病毒 1 型 (HIV-1) 的高效复制，并作为潜伏病毒库的关键组成部分。然而，该潜伏病毒库的病毒特征以及该病毒库的临床相关性仍不清楚。在这项研究中，我们评估了接受抑制性联合抗逆转录病毒治疗 (cART) 的 HIV-1 感染者的外周 TFH (pTFH)、非 TFH 记忆细胞和初始 CD4 T 细胞中潜伏病毒的热带组成。与其他两个亚群中的水平相比，pTFH 细胞中优先富集 X4 向性潜伏 HIV-1。有趣的是，pTFH 细胞中 X4 向性潜伏 HIV-1 的比例不仅与患者的血液 CD4 T 细胞计数呈显着负相关，而且还是长期 cART 个体 CD4 T 细胞恢复的预后。此外，pTFH细胞中X4倾向性潜伏HIV-1比率较高的患者表现出更大的机会性合并感染风险。这些发现揭示了TFH细胞中潜伏HIV-1的特征，并表明pTFH细胞中X4向性潜伏HIV-1的比例是疾病进展和cART疗效的一个有价值的指标。
Follicular helper T (TFH) cells have been shown to support productive.human immunodeficiency virus type 1 (HIV-1) replication and to serve as a key component.of the latent viral reservoir. However, the viral characteristics of this latent.reservoir and the clinical relevance of this reservoir remain unclear. In this study, we.assessed the tropic composition of latent viruses from peripheral TFH (pTFH), non-.TFH memory, and naive CD4 T cells from individuals with HIV-1 infections on suppressive.combined antiretroviral therapy (cART). X4-tropic latent HIV-1 was preferentially.enriched in pTFH cells compared to levels in the other two subsets..Interestingly, the ratio of X4-tropic latent HIV-1 in pTFH cells not only was robustly.and inversely correlated with blood CD4 T cell counts across patients but also was.prognostic of CD4 T cell recovery in individuals on long-term cART. Moreover, patients.with higher X4-tropic latent HIV-1 ratios in pTFH cells showed greater risks of.opportunistic coinfections. These findings reveal the characteristics of latent HIV-1 in.TFH cells and suggest that the ratio of X4-tropic latent HIV-1 in pTFH cells is a valuable.indicator for disease progression and cART efficacy.