A PHARMACOLOGICAL DISTINCTION BETWEEN THE LONG AND SHORT LATENCY PATHWAYS OF THE HUMAN BLINK REFLEX REVEALED WITH TOBACCO
A PHARMACOLOGICAL DISTINCTION BETWEEN THE LONG AND SHORT LATENCY PATHWAYS OF THE HUMAN BLINK REFLEX REVEALED WITH TOBACCO
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DOI：
10.1007/bf00406604
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发表时间：
1988-01-01
影响因子：
2
通讯作者：
FIERO, RA
中科院分区：
文献类型：
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作者：
EVINGER, C;SIBONY, PA;FIERO, RA
在三名正常人类受试者中，吸烟被用作药理学探针，以差异性地改变眨眼反射背后的直接和间接途径。吸烟后，电刺激三叉眶上神经诱发的眼轮匝肌电图间接 R2 成分的潜伏期短暂增加 20-80%，而较短潜伏期的直接 RI 成分的潜伏期保持不变。眨眼反射的两个成分的强度都短暂下降。数据表明，吸烟可以不同地改变眨眼反射的长潜伏期和短潜伏期成分，并表明这些影响是由于对尼古丁敏感的中枢通路的改变造成的。
In three, normal, human subjects, tobacco smoking was used as a pharmacological probe to modify differentially the direct and indirect pathways underlying the blink reflex. The latency of the indirect R2 component of the orbicularis oculis electromyogram evoked by electrical stimulation of the trigeminal supraorbital nerve transiently increased 20-80% after smoking, while the latency of the shorter latency, direct RI component remained constant. The magnitude of both components of the blink reflex transiently decreased. The data demonstrate that tobacco smoking can differentially alter the long and short latency components of the blink reflex, and suggest that these effects result from modifications of cental pathways sensitive to nicotine.