The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways
The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways
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DOI：
10.1124/jpet.103.051797
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发表时间：
2003-09-01
影响因子：
3.5
通讯作者：
Cussac, D
中科院分区：
文献类型：
--
作者：
Millan, MJ;Gobert, A;Cussac, D
阿戈美拉汀（S20098）在天然（猪）和克隆人（h）5-羟色胺（5-HT）（2C）受体上的pK（i）值分别为6.4和6.2。它还与h5-HT 2B受体相互作用（6.6），而它对天然（大鼠）/克隆的人5-HT 2A（
Agomelatine (S20098) displayed pK(i) values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)(2C) receptors, respectively. It also interacted with h5-HT2B receptors (6.6), whereas it showed low affinity at native (rat)/cloned, human 5-HT2A (