Point: population stratification: a problem for case-control studies of candidate-gene associations?

Point: population stratification: a problem for case-control studies of candidate-gene associations?
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DOI：
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发表时间：
2002-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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通讯作者：
Duncan C. Thomas;J. Witte
Duncan C. Thomas;J. Witte
中科院分区：
其他
文献类型：
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作者：
Duncan C. Thomas;J. Witte

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The case-control design is a widely used approach for investigating associations between candidate genes and dichotomous disease traits. As mostcommonly implemented, cases are drawn from a population-baseddisease registry and unrelated controls from their source population, perhaps matching on age,