The art and science of engineering hybrid living/non-living mechanical devices
The art and science of engineering hybrid living/non-living mechanical devices
复制标题
工程混合生命/非生命机械装置的艺术和科学
DOI：
10.1109/memsys.2002.984041
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
H. Neves
中科院分区：
文献类型：
--
作者：
C. Montemagno;H. Neves
我们已经展示了由微米和纳米制造部件和生物单元组成的混合系统的构造。这种集成已在纳米级和微米级水平上完成。生物部件与纳米和微米制造结构的集成开辟了将生物复杂性纳入所得系统的可能性，最终导致以前不可行的系统的实现。生物运动结构，从其基本成分（例如放线肌球蛋白复合物）到肌管和完整的肌肉组织，都具有非常高的效率，这是目前其他常用的 MEMS 驱动方法所无法比拟的。潜在的应用范围广泛，从医疗植入物到自主侦察系统。讨论了我们的制造工艺和集成协议的细节，以及可能影响未来工作的集成问题。
We have demonstrated the construction of hybrid systems comprised of microand nanofabricated parts and biological units. This integration has been accomplished at both nanoscale and microscale levels. The integration of biological parts with nano- and microfabricated structures opens up the possibility of incorporating biological complexity to the resulting systems, ultimately leading to the realization of systems that were not previously feasible. Biological motility structures, ranging from their basic constituents - such as the actinomyosin complex - to myotubules and complete muscle tissue have very high efficiency not currently matched by other commonly used methods of MEMS actuation. Potential applications range widely from medical implants to autonomous reconnaissance systems. Specifics of our fabrication processes and integration protocols are discussed, as well as integration issues that are likely to impact on future work.