Post-synthetic modification of an amino-functionalized metal-organic framework for highly efficient enrichment of N-linked glycopeptides
Post-synthetic modification of an amino-functionalized metal-organic framework for highly efficient enrichment of N-linked glycopeptides
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DOI：
10.1039/c6nr02490d
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发表时间：
2016-01-01
期刊：
影响因子：
6.7
通讯作者：
Liu, Huwei
中科院分区：
文献类型：
--
作者：
Ma, Wen;Xu, Linnan;Liu, Huwei
通过对MIL-101（Cr）-NH 2进行简单的两步合成后修饰，开发了麦芽糖官能化的金属有机框架（MOF），MIL-101（Cr）-麦芽糖。使用这种纳米材料，从人免疫球蛋白G的消化物中检测到33种糖肽，证明了其在糖蛋白组学分析中的高效性。更重要的是，氨基衍生的MOFs的通用功能化路线为样品制备中的材料设计开辟了新的视角。
A maltose-functionalized metal-organic framework (MOF), MIL-101(Cr)-maltose, was developed via a simple two step post-synthetic modification of MIL-101(Cr)-NH2. With the use of this nanomaterial, 33 glycopeptides were detected from the digest of human immunoglobulin G, demonstrating its high efficiency in glycoproteomic analysis. More importantly, the generic functionalization route from amino-derived MOFs opens a new perspective in material design in sample preparation.