Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake.
Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake.
复制标题
DOI：
10.1038/jhh.2012.22
复制
发表时间：
2013-03
影响因子：
2.7
通讯作者：
中科院分区：
文献类型：
--
作者：
血清和糖皮质激素诱导激酶1（SGK 1）在远端肾单位上皮钠通道（ENaC）依赖性Na+转运中起核心作用。我们假设SGK 1基因变异可能有助于高血压患者饮食盐摄入对血压的影响，并因此影响肾素-血管紧张素-醛固酮（RAA）系统的活性。我们的研究人群包括HyperPath组的421名高血压白人参与者，他们完成了饮食盐方案，测量了BP和RAA系统活性。来自HapMap CEU人群的三个SGK 1标记单核苷酸多态性（SNP）捕获了SGK 1区域的遗传变异。假设一个加性遗传模型，两个SNPs（rs 2758151和rs 9402571）与血压和血浆肾素活性（PRA）的饮食盐摄入量的影响。主要等位基因与高盐时收缩压升高和低盐时PRA降低相关。相反，低盐中和了基因型差异。在血压正常人群（N=152）中观察到类似的非显著趋势。基因型也与高血压的两种盐敏感亚型相关。SGK 1基因变异与高血压患者BP和PRA盐敏感性相关这些SGK 1变体的基因型状态可以识别出容易患盐敏感性高血压的个体。
Serum- and glucocorticoid-inducible kinase 1 (SGK1) plays a central role in epithelial sodium channel (ENaC)-dependent Na+ transport in the distal nephron. We hypothesized that SGK1 gene variants may contribute to the effect of dietary salt intake on BP in humans with hypertension, and consequentially influence renin-angiotensin-aldosterone (RAA) system activity. Our study population included 421 hypertensive Caucasian participants of the HyperPath group who had completed a dietary salt protocol with measurement of BP and RAA system activity. Three SGK1 tagging single nucleotide polymorphisms (SNPs) from the HapMap CEU population captured the genetic variation in the SGK1 region. Assuming an additive genetic model, two SNPs (rs2758151 and rs9402571) were associated with BP and plasma renin activity (PRA) effects of dietary salt intake. Major alleles were associated with higher systolic BP on high salt and decreased PRA on low salt. In contrast, low salt neutralized genotype differences. Similar, non-significant trends were observed in a normotensive population (N=152). Genotype was also associated with two salt-sensitive subtypes of hypertension. SGK1 genetic variants are associated with salt sensitivity of BP and PRA in human hypertension. Genotype status at these SGK1 variants may identify individuals prone to salt-sensitive hypertension.
登录
查看更多内容
影响因子：
4.9
作者：
Hopkins, PN;Lifton, RP;Williams, GH
通讯作者：
Williams, GH
DOI：
10.1073/pnas.96.5.2514
发表时间：
1999-03-02
影响因子：
11.1
作者：
Chen, SY;Bhargava, A;Pearce, D
通讯作者：
Pearce, D
影响因子：
8.3
作者：
Price, DA;Fisher, NDL;Hollenberg, NK
通讯作者：
Hollenberg, NK
影响因子：
7.1
作者：
Luft, Friedrich C.;Weinberger, Myron H.
通讯作者：
Weinberger, Myron H.
影响因子：
4.9
作者：
Patel, Tejas V.;Williams, Gordon H.;Fisher, Naomi Deirdre L.
通讯作者：
Fisher, Naomi Deirdre L.