CONGENITAL HYPOTHYROIDISM IN SWEDEN - PSYCHOMOTOR DEVELOPMENT IN PATIENTS DETECTED BY CLINICAL SIGNS AND SYMPTOMS
CONGENITAL HYPOTHYROIDISM IN SWEDEN - PSYCHOMOTOR DEVELOPMENT IN PATIENTS DETECTED BY CLINICAL SIGNS AND SYMPTOMS
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DOI：
10.1111/j.1651-2227.1981.tb06249.x
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
ZETTERSTROM, R
中科院分区：
文献类型：
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作者：
ALM, J;LARSSON, A;ZETTERSTROM, R
对39例7-9岁先天性甲状腺功能减退症患儿的智力、神经功能和社会功能进行了研究。根据WISC（韦氏儿童智力量表）测试，他们的智力成就显著低于参考人群（平均智商88，范围50-113）。在出生后5周内出现甲状腺功能减退症症状和体征的儿童中，开始治疗的年龄与智力发育呈负相关。在出生后4周出现体征和症状的儿童中没有发现这种相关性。在新生儿期甲状腺功能减退症的26名儿童中，有9名儿童被发现有神经系统异常，包括精细和粗大运动障碍。神经系统异常严重影响日常生活，只有2个最严重的弱智。未发现治疗开始时的年龄与神经系统异常之间存在相关性。3名儿童因智力迟钝而上特殊学校，6名儿童上普通学校，但因学习障碍需要额外的教学援助。对新生儿期甲状腺功能减退症患儿进行早期治疗，可降低未来智力障碍的风险。
Children (39) at 7-9 yr of age with congenital hypothyroidism were studied with respect to their intellectual, neurological and social functions. Their intellectual achievement as assessed by the WISC (Wechsler Intelligence Scale for Children) test, was significantly lower than in a reference population (mean IQ 88, range 50-113). In children who showed signs and symptoms of hypothyroidism during their first 5 wk of life, there was a negative correlation between the age when therapy was started and intellectual development. No such correlation was found in children who showed signs and symptoms after the first 4 wk of life. Nine children of 26 with signs of hypothyroidism in the neonatal period were found to have neurological abnormalities consisting of fine and gross motor disturbances. The neurological abnormalities seriously affected daily life in only the 2 most severely mentally retarded. No correlation was found between the age when the therapy was started and neurological abnormalities. Three children attended special schools because of mental retardation and 6 attended normal schools but required additional teaching assistance for learning disabilities. The risk of future intellectual handicaps may be reduced by early treatment in children with hypothyroidism presenting during the neonatal period.