Gastric emptying of solid food in normal man and after subtotal gastrectomy and truncal vagotomy with pyloroplasty.
Gastric emptying of solid food in normal man and after subtotal gastrectomy and truncal vagotomy with pyloroplasty.
复制标题
正常人胃大部切除术和幽门成形术迷走神经干切除术后固体食物的胃排空。
DOI：
10.1016/s0016-5085(77)80073-5
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发表时间：
1977
期刊：
影响因子：
29.4
通讯作者：
J. Meyer
中科院分区：
文献类型：
--
作者：
Ian L. MacGregor;P. Martin;J. Meyer
胃排空的改变被认为与消化性溃疡手术的许多后遗症有关。一种有效的固体食物标签方法的应用使正常受试者、胃大部切除术、迷走神经切断术和幽门成形术(V&P)的胃排空速度和模式的测量成为可能。正常人的平均排空率为27.96%/h，呈线性规律。胃大部切除术患者的排空模式可分为三个阶段，总体上接近指数模式，平均速率常数为0.030分钟−1，t1/2为23.3min。V&P受试者分为两组：(1)慢排空，呈线性模式，平均速度为17.64%/小时；(2)快速排空，呈指数模式，平均速度常数为0.039分钟，−为1，t_(1/2)为17.7min。在V&P组中，有一半的患者胃排空速度慢，乳糜酶通过小肠的速度慢，可能允许更高的消化和吸收效率，这可能是V&P后总体营养紊乱不那么严重的原因。
Alterations in gastric emptying are considered contributory to many sequelae of peptic ulcer surgery. The application of a validated method of firmly tagging solid food has enabled the measurement of the rates and patterns of gastric emptying in normal subjects, subtotal gastrectomy, and vagotomy and pyloroplasty (V&P). Normal persons emptied with a linear pattern at a mean rate of 27.96% per hr. Subtotal gastrectomy patients showed up to three phases in their emptying pattern, which, over all, approximated an exponential pattern, with a mean rate constant of 0.030 min−1and calculatedt1/2of 23.3 min. V&P subjects divided into two groups: (1) slow emptying with a linear pattern and mean rate of 17.64 % per hr; (2) rapid emptying with exponential pattern and mean rate constant of 0.039 min−1,t1/2of 17.7 min. The slow gastric emptying rate and slow passage of chyme through the small intestine in one-half of the V&P group presumably allows greater efficiency of digestion and absorption and may account for the over-all less severe nutritional disturbances after V&P.