Coordination of NMDA-induced rhythmic activity in the trigeminal and hypoglossal nerves of neonatal mice in vitro
Coordination of NMDA-induced rhythmic activity in the trigeminal and hypoglossal nerves of neonatal mice in vitro
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DOI：
10.1016/j.neures.2012.11.003
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发表时间：
2013-02-01
影响因子：
2.9
通讯作者：
Inoue, Tomio
中科院分区：
文献类型：
--
作者：
Ihara, Yoshiaki;Nakayama, Kiyomi;Inoue, Tomio
吮吸是一种有节奏的下颌运动，左右对称，与舌头运动高度协调。因此，我们调查的神经元机制的左/右和颌/舌协调N-甲基-U-天冬氨酸（NMDA）诱导的虚构的吸吮使用分离的脑干脊髓制备获得新生小鼠。我们观察到同步的低频节律活动在左/右三叉神经运动神经，这不同于呼吸，和高频节律三叉神经活动，这是侧独立的。三叉神经低频节律活动与舌下神经活动同步。在完全中线分离标本或部分中线横断脑干（从小脑前下动脉到椎动脉交界处）后，低频节律性三叉神经活动消失，而高频节律性三叉神经活动和低频节律性舌下神经活动仍然存在。这些结果表明，产生低频节律活动的神经元网络可能有助于左/右颌肌和颌/舌肌的同步活动，在那里它主要通过穿过横断中线区域的连合通路将其命令发送到三叉神经运动神经元。这种神经元网络可能是哺乳期间下颌和舌头协调运动的基础。(C)2012 Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
Suckling is a rhythmic jaw movement that is symmetrical on the left and right side and is highly coordinated with tongue movement. Thus, we investigated the neuronal mechanisms of the left/right and jaw/tongue coordinations during N-methyl-u-aspartate (NMDA)-induced fictive suckling using isolated brainstem-spinal cord preparations obtained from neonatal mice. We observed synchronous low-frequency rhythmic activity in the left/right trigeminal motor nerves, which differed from respiration, and high-frequency rhythmic trigeminal activity, which was side-independent. The low-frequency rhythmic trigeminal activity was also synchronized with the hypoglossal nerve activity. After a complete midline separation of the preparation or a partial midline transection of the brainstem from the anterior inferior cerebellar artery to the junction of the vertebral artery, the low-frequency rhythmic trigeminal activity disappeared, whereas the high-frequency rhythmic trigeminal activity and low-frequency rhythmic hypoglossal activity still remained. These results suggest that the neuronal network that generates low-frequency rhythmic activity likely contributes to the synchronized activity of the left/right jaw muscles and to the jaw/tongue muscles, where it sends its command to the trigeminal motoneurons mainly via the commissural pathway that crosses the transected midline region. Such a neuronal network may underlie the coordinated movements of the jaw and tongue during suckling. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.