Human adipose-derived stem cells and three-dimensional scaffold constructs: a review of the biomaterials and models currently used for bone regeneration.
Human adipose-derived stem cells and three-dimensional scaffold constructs: a review of the biomaterials and models currently used for bone regeneration.
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DOI：
10.1002/jbm.b.32817
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
A. S. Zanetti;C. Sabliov;J. Gimble;D. Hayes
中科院分区：
文献类型：
--
作者：
A. S. Zanetti;C. Sabliov;J. Gimble;D. Hayes
在过去的十年中，在骨再生中使用人脂肪源性基质/干细胞（hASC）已经取得了实质性进展。自从发现hASC的成骨潜力以来，许多模型已经将hASC与可生物降解的支架材料相结合。一般来说，大鼠和非负重骨形成的免疫缺陷（裸）小鼠模型已经引领了评估hASC体内成骨潜力的方法。本综述的目的是提出一个概述最近的文献描述hASC成骨结合三维支架骨再生。
In the past decade, substantial strides have been taken toward the use of human adipose-derived stromal/stem cells (hASC) in the regeneration of bone. Since the discovery of the hASC osteogenic potential, many models have combined hASC with biodegradable scaffold materials. In general, rats and immunodeficient (nude) mice models for nonweight bearing bone formation have led the way to assess hASC osteogenic potential in vivo. The goal of this review is to present an overview of the recent literature describing hASC osteogenesis in conjunction with three-dimensional scaffolds for bone regeneration.