Reagent-dependent pseudo-prolongation of activated partial thromboplastin time
Reagent-dependent pseudo-prolongation of activated partial thromboplastin time
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活化部分凝血活酶时间的试剂依赖性假性延长
DOI：
10.11406/rinketsu.62.1515
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
小島 研介
中科院分区：
文献类型：
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作者：
宮﨑 詩織;西田 愛恵;朝霧 正;重留 一貴;木田 和伸;久川 浩章;砥谷 和人;小島 研介
我们报告一例伪延长活化部分凝血活素时间（APTT），这被怀疑是由动物来源的磷脂引起的。一名78岁妇女因不明原因的APTT延长而转诊至我院。她患有代偿性酒精性肝硬化，血小板计数轻度下降，凝血酶原时间正常，无出血倾向。使用兔脑提取磷脂的APTT为66秒，而使用合成磷脂的APTT为34.9秒。APTT的人为伪延长似乎归因于试验试剂对低因子XII水平的敏感性。因此，不同APTT试剂的检测对医生诊断类似病例是有用的。
We report a case of pseudo-prolongation of activated partial thromboplastin time (APTT), which was suspected to be caused by an animal-derived phospholipid. A 78-year-old woman was referred to our hospital because of an unexplained APTT prolongation. She had compensated alcoholic liver cirrhosis, with modestly decreased platelet count and normal prothrombin time, and no bleeding tendency. The APTT was 66 seconds in a test using phospholipid extracted from rabbit brain but was 34.9 seconds with synthetic phospholipids. The artifactual pseudo-prolongation of the APTT was seemingly attributable to the susceptibility of the test reagents to low factor XII levels. Thus, tests with different APTT reagents would be useful to physicians in the diagnosis of similar cases.