Congenital heart disease in the general population - Changing prevalence and age distribution
Congenital heart disease in the general population - Changing prevalence and age distribution
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DOI：
10.1161/circulationaha.106.627224
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发表时间：
2007-01-16
期刊：
影响因子：
37.8
通讯作者：
Pilote, Louise
中科院分区：
文献类型：
--
作者：
Marelli, Ariane J.;Mackie, Andrew S.;Pilote, Louise
背景--关于先天性心脏病(CHD)流行病学变化的经验数据很少。我们确定了从1985年到2000年患有严重和其他形式冠心病的成人和儿童的患病率、年龄分布和比例。方法和结果-在医疗保健普及的情况下，我们使用系统地记录所有诊断和索赔的行政数据库。诊断代码符合国际疾病分类第九版。重度CHD定义为法洛四联症、动脉干、移位复合体、心内膜垫缺陷症和单室心。1985年、1990年、1995年和2000年，使用魁北克省的人口数字确定了严重和其他冠心病病变的患病率。研究对象为18岁的儿童。2000年，所有冠心病的患病率为4.09/1000成年人，严重病变的患病率为0.38/1000(9%)。女性受试者占成年冠心病人口的57%。严重冠心病患者的平均年龄在1985年为11岁(四分位数范围，4-22岁)，在2000年为17岁(四分位数范围，10-28岁)(P<；0.0001)。从1985年到2000年，严重冠心病的患病率有所上升，但成年人的增幅明显高于儿童。2000年，49%的重症冠心病患者是成年人。结论：从1985年到2000年，成人重症冠心病的患病率和普通人群中重度冠心病患者的中位年龄呈上升趋势。2000年，患有严重冠心病的成人和儿童人数几乎相等。
Background - Empirical data on the changing epidemiology of congenital heart disease ( CHD) are scant. We determined the prevalence, age distribution, and proportion of adults and children with severe and other forms of CHD in the general population from 1985 to 2000.Methods and Results - Where healthcare access is universal, we used administrative databases that systematically recorded all diagnoses and claims. Diagnostic codes conformed to the International Classification of Disease, ninth revision. Severe CHD was defined as tetralogy of Fallot, truncus arteriosus, transposition complexes, endocardial cushion defects, and univentricular heart. Prevalence of severe and other CHD lesions was determined in 1985, 1990, 1995, and 2000 using population numbers in Quebec. Children were subjects < 18 years of age. The prevalence was 4.09 per 1000 adults in the year 2000 for all CHD and 0.38 per 1000 ( 9%) for those with severe lesions. Female subjects accounted for 57% of the adult CHD population. The median age of all patients with severe CHD was 11 years ( interquartile range, 4 to 22 years) in 1985 and 17 years ( interquartile range, 10 to 28 years) in 2000 ( P < 0.0001). The prevalence of severe CHD increased from 1985 to 2000, but the increase in adults was significantly higher than that observed in children. In the year 2000, 49% of those alive with severe CHD were adults.Conclusions - The prevalence in adults and median age of patients with severe CHD increased in the general population from 1985 to 2000. In 2000, there were nearly equal numbers of adults and children with severe CHD.