BABESIA-RODHAINI - REQUIREMENT OF COMPLEMENT FOR PENETRATION OF HUMAN ERYTHROCYTES
BABESIA-RODHAINI - REQUIREMENT OF COMPLEMENT FOR PENETRATION OF HUMAN ERYTHROCYTES
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DOI：
10.1126/science.841340
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
WARD, PA
中科院分区：
文献类型：
--
作者：
CHAPMAN, WE;WARD, PA
建立了一种体外系统，其中人红细胞在新鲜人（或大鼠）血清存在下被血孢子虫原虫B寄生。rodhaini。B的能力。rodhaini穿透红细胞依赖于补体旁路途径的因子（备解素和因子B）以及Mg 2+和补体的第3（C3）和第5（C5）组分。这些数据表明寄生虫能够利用补体系统的新机制。这些数据与早期观察结果雅阁，并进一步证实了大鼠巴贝斯虫感染发展中对补体的需求。
A system was developed in vitro in which human red cells, in the presence of fresh human (or rat) serum, were parasitized by the hemosporidian protozoan B. rodhaini. The ability of B. rodhaini to penetrate red cells depended on factors of the alternative complement pathway (properdin and factor B) as well as Mg2+ and the 3rd (C3) and the 5th (C5) components of complement. These data indicate a novel mechanism by which a parasite is able to utilize the complement system. The data are in accord with and amplify earlier observations that demonstrated a requirement for complement in the development of babesial infection in rats.