Impaired fasting glucose, type 2 diabetes mellitus, and lifetime risk of cardiovascular disease among women and men: the Rotterdam Study.
Impaired fasting glucose, type 2 diabetes mellitus, and lifetime risk of cardiovascular disease among women and men: the Rotterdam Study.
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DOI：
10.1136/bmjdrc-2021-002406
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发表时间：
2021-08
影响因子：
4.1
通讯作者：
Kavousi M
中科院分区：
文献类型：
--
作者：
Ahmadizar F;Wang K;Aribas E;Fani L;Heshmatollah A;Ikram MK;Kavousi M
关于整个血糖谱的特定性别的心血管疾病(CVD)终生风险的数据，特别是在空腹血糖受损(IFG)状态下，数据很少。超重/肥胖是否会改变心血管疾病的负担也尚不清楚。采用鹿特丹前瞻性人群研究，定义了正常血糖、空腹血糖和2型糖尿病(T2D)。在截至2015年1月1日的一段时间内，首次发生冠心病、心力衰竭和中风的病例被确定并形成复合心血管疾病终点。在55岁、65岁、75岁和85岁的每一种葡萄糖类别中，使用根据相互竞争的死亡风险调整的生存分析的修改版本，估计了心血管疾病的剩余终身风险。在基线无心血管疾病的5698名女性和3803名男性中，平均年龄为64.5岁(SD 9.6)，60.0%的参与者是女性。在55岁时，IFG组女性发生任何心血管事件的剩余终身风险为55.1%(95%CI 48.3~61.9)，而正常血糖组为52.7%(95%CI 49.5~55.9)，T2D组为61.5%(95%CI 54.7~68.3)。对于男性来说，IFG组发生任何心血管事件的剩余终身风险为62.1%(95%CI 55.2至69.1)，而正常血糖组为59.1%(95%CI 55.5至62.7)，T2D组为60.3%(95%CI 53.1至67.5)。在55岁时，与正常体重的女性和男性相比，患有IFG的超重或肥胖的女性和男性发生心血管疾病的终身风险更高，尽管在统计学上没有显著意义。与正常血糖相比，IFG在女性和男性中发生心血管事件的终生风险都很大。尤其是在男性中，这种风险与T2D相当。超重/肥胖改变了风险，并在患有IFG的女性和男性中赋予了更大的终生心血管风险负担。
Data on sex-specific lifetime risk of cardiovascular disease (CVD) across the glycemic spectrum, in particular in impaired fasting glucose (IFG) state, are scarce. Whether overweight/obesity modifies the CVD burden also remains unclear. Using a prospective population-based Rotterdam Study, normoglycemia, IFG, and type 2 diabetes mellitus (T2D) were defined. First incident cases of coronary heart disease, heart failure, and stroke during a follow-up time until January 1, 2015 were identified and formed the composite CVD end point. The remaining lifetime risks of CVD were estimated in each glucose category at 55, 65, 75, and 85 years of age, using a modified version of survival analysis adjusted for the competing risk of death. Among 5698 women and 3803 men free of CVD at baseline, the mean age was 64.5 years (SD 9.6) and 60.0% of participants were women. At age 55 years, the remaining lifetime risk of any CVD event among women was 55.1% (95% CI 48.3 to 61.9) for IFG, compared with 52.7% (95% CI 49.5 to 55.9) for normoglycemia and 61.5% (95% CI 54.7 to 68.3) for T2D. For men, the remaining lifetime risk of any CVD event was 62.1% (95% CI 55.2 to 69.1) for IFG, compared with 59.1% (95% CI 55.5 to 62.7) for normoglycemia and 60.3% (95% CI 53.1 to 67.5) for T2D. At age 55 years, the lifetime risk for incident CVD was higher, although not statistically significant, among women and men with IFG who were overweight or had obesity compared with normal-weight women and men. IFG carried a large lifetime risk for incident CVD among both women and men compared with normoglycemia. In particular among men, the risk was comparable to that of T2D. Overweight/Obesity modifies the risk and conferred a larger burden of lifetime CVD risk among women and men with IFG.
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DOI：
10.1136/bmj.i5953
发表时间：
2016-11-23
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Huang Y;Cai X;Mai W;Li M;Hu Y
通讯作者：
Hu Y
DOI：
10.1016/j.ecl.2017.10.001
发表时间：
2018-03
影响因子：
4.5
作者：
Brannick B;Dagogo-Jack S
通讯作者：
Dagogo-Jack S
影响因子：
16.2
作者：
Vistisen, Dorte;Witte, Daniel R.;Faerch, Kristine
通讯作者：
Faerch, Kristine
终生风险和心血管疾病首发表现的性别差异：基于人群的前瞻性队列研究。
DOI：
10.1136/bmj.g5992
发表时间：
2014-11-17
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Leening MJ;Ferket BS;Steyerberg EW;Kavousi M;Deckers JW;Nieboer D;Heeringa J;Portegies ML;Hofman A;Ikram MA;Hunink MG;Franco OH;Stricker BH;Witteman JC;Roos-Hesselink JW
通讯作者：
Roos-Hesselink JW
影响因子：
1.3
作者：
Li, Jianing;Scheike, Thomas H.;Zhang, Mei-Jie
通讯作者：
Zhang, Mei-Jie