Denicotinized Versus Average Nicotine Tobacco Cigarette Smoking Differentially Releases Striatal Dopamine
Denicotinized Versus Average Nicotine Tobacco Cigarette Smoking Differentially Releases Striatal Dopamine
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DOI：
10.1093/ntr/nts029
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发表时间：
2013-01-01
影响因子：
4.7
通讯作者：
Zubieta, Jon-Kar
中科院分区：
文献类型：
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作者：
Domino, Edward F.;Ni, Lisong;Zubieta, Jon-Kar
长期以来，尼古丁一直被认为是香烟中必要的成分，但不足以维持吸烟的心理生理需要。本研究检测了戒烟一夜后尼古丁对纹状体多巴胺（DA）释放的静脉血浆浓度影响。在单盲条件下，22名男性吸烟者抽去尼古丁（denic）或普通尼古丁（nic）香烟。每个人都给予[C-11]氯胺酮，并在正电子发射断层扫描（PET）设备中进行扫描。吸黑烟或尼古丁香烟都会释放纹状体DA。吸烟主要在右侧纹状体释放多巴胺，而吸烟则在两个纹状体释放多巴胺，但在左侧纹状体释放的多巴胺最多。静脉血浆尼古丁浓度升高与左尾状核DA释放增加呈正相关。吸普通香烟和吸普通香烟一样能减少对香烟的渴望。尼古丁吸烟后渴望减少与血浆尼古丁增加相关。吸烟中的非尼古丁因素会对右脑产生重要影响。尼古丁是吸烟过程中释放双侧纹状体DA的一种药理因素，但在左脑释放更多。
Nicotine has long been recognized as a necessary but insufficient component of tobacco cigarettes to maintain a psychophysiological need to smoke. This study examined venous plasma concentrations effects of nicotine in cigarette smoking after overnight abstinence to release striatal dopamine (DA).Twenty-two male smokers smoked either denicotinized (denic) or average nicotine (nic) cigarettes under single blind conditions. Each was given [C-11]raclopride and scanned in a positron emission tomography (PET) facility.Smoking either denic or nic cigarettes released striatal DA. Denic cigarette smoking released DA primarily in the right striatum, whereas nic cigarette smoking released DA in both striata, but especially in the left. Increases in venous plasma nicotine concentrations correlated positively with increased DA release in the left caudate nucleus. Smoking denic cigarettes reduced craving as much as smoking nic cigarettes. Craving reduction after nic tobacco smoking correlated with increases in plasma nicotine.Nonnicotine factors in tobacco smoking produce important right brain effects. Nicotine is a pharmacological factor during tobacco smoking that releases bilateral striatal DA, but more in the left brain.