Performance of the modified Systemic Manifestation Score for systemic juvenile idiopathic arthritis in Adult-onset Still’s disease-猫眼课题宝

DOI：

10.1007/s10067-022-06340-7

发表时间：

2022-08

期刊：

Clinical Rheumatology

影响因子：

3.4

通讯作者：

中科院分区：

医学3区

文献类型：

作者：

Dehao Zhu;Jianfen Meng;Jinchao Jia;Mengyan Wang;Yuning Ma;Hui Shi;Yue Sun;Honglei Liu;Xiaobing Cheng;Yutong Su;Junna Ye;Huihui Chi;Tingting Liu;Zhihong Wang;Liyan Wan;Zhuochao Zhou;Fan Wang;Xia Chen;Chengde Yang;Qiong-yi Hu;Jialin Teng

目的比较改良的系统症状评分(MSMS)和mPouchot评分在大队列中区分成人起病斯蒂尔病(AOSD)严重程度高的能力。研究MSMS和mPouchot评分与血沉、C反应蛋白、铁蛋白、肝功能和血清细胞因子的相关性。结果MSMS和mPouchot评分与血沉(P&lt； 0.001)、C反应蛋白(P&l； 0.0001)、血清铁蛋白(P&l； 0.0001)呈正相关。此外，MSMS和mPouchot评分与AOSD患者的肝功能障碍和高IL-18(P&lt； 0.0001)和IL-6(P&lt； 0.01)水平显著相关。此外，MSM的曲线下面积(AUC值)显著小于mPouchot评分(P&lt； 0.0001)。与mPouchot评分相比，MSMS具有更高的敏感性(75.64%比74.36%)和更低的特异性(55.06%比76.40%)。结论MSM和mPouchot评分均能有效评估AOSD的病情严重程度。相比之下，MSM在评估AOSD患者病情严重程度方面的表现不如mPouchot评分。关键点·改良系统症状评分(MSMS)和改良Pouchot评分(mPouchot评分)都与AOSD患者的血沉、CRP和血清铁蛋白呈正相关。·这两个评分都与肝功能受损和血清细胞因子水平显著相关。·MSMS在区分AOSD患者病情严重程度方面低于mPouchot评分。

ObjectivesTo compare the ability of the modified Systemic Manifestation Score (mSMS) and the mPouchot score to distinguish adult-onset Still’s disease (AOSD) with high disease severity in a large cohort.MethodsWe scored the disease severity of 174 patients and categorized them into high and low disease severity states. The correlation of mSMS and mPouchot score with ESR, CRP, ferritin, liver function tests, and serum cytokines was investigated. Receiver operator characteristic (ROC) curve and logistic regression analysis were performed to compare the ability of mSMS and mPouchot to distinguish patients with severe AOSD.ResultsBoth mSMS and mPouchot score were positively correlated with ESR (bothP< 0.001), CRP (bothP< 0.0001), and serum ferritin (bothP< 0.0001). Moreover, both mSMS and mPouchot score are significantly associated with liver dysfunction and high IL-18 (bothP< 0.0001) and IL-6 (bothP< 0.01) levels in AOSD patients. Furthermore, the area under curve (AUC) value of mSMS was significantly less than of mPouchot score (0.71 for mSMS, 0.81 for mPouchot score,P< 0.0001). Compared with mPouchot score, mSMS had higher sensitivity (75.64% vs 74.36%) and lower specificity (55.06% vs 76.40%). And mSMS had a worse performance in assessing high disease severity than mPouchot score in logistic analysis.ConclusionBoth scores are proven as effective to assess disease severity of AOSD. By contrast, mSMS perform worse in assessing high disease severity of AOSD patients than mPouchot score.Key Points• Both modified Systemic Manifestation Score (mSMS) and modified Pouchot score (mPouchot score) positively correlated with ESR, CRP, and serum ferritin of AOSD patients.• Both scores are significantly associated with impaired liver function and high serum cytokine levels.• mSMS had lower discriminative ability than mPouchot score to distinguish high disease severity of AOSD patients.

Performance of the modified Systemic Manifestation Score for systemic juvenile idiopathic arthritis in Adult-onset Still’s disease

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