Leptin concentration in newborns' cord blood:: relationship to gender and growth-regulating hormones
Leptin concentration in newborns' cord blood:: relationship to gender and growth-regulating hormones
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DOI：
10.1038/sj.ijo.0801023
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发表时间：
1999-09-01
影响因子：
4.9
通讯作者：
Tatò, L
中科院分区：
文献类型：
--
作者：
Maffeis, C;Moghetti, P;Tatò, L
目标：验证新生儿出生时血浆瘦素浓度是否在性别之间存在显著差异;并研究出生时血浆瘦素与生长调节激素之间的潜在相互作用。98名健康新生儿（48名男性，50名女性）进行了研究，瘦素，胰岛素，皮质醇，胰岛素样生长因子-1（IGF-1），睾酮，结果：新生儿血清瘦素浓度平均为8.05（0.5）ng/ml，新生儿血清瘦素浓度平均为8.05（0.5）ng/ml。女性血清瘦素水平显著高于男性[9.6（0.8）vs 6.0（0.6）ng/ml]（P < 0.005）。女性IGF-1显著高于男性[87（4）vs 74（5）μ g/l]（P < 0.05），而SHBG略低[29（1）vs 33（2）nmol/l]。两种性别之间的胰岛素、皮质醇和睾酮血清浓度无统计学差异。在所检查的变量中，出生体重（以体重Z值表示）和胰岛素与新生儿血清瘦素的相关程度最高（r分别为0.48和0.31，P < 0.001）。多元回归分析显示，出生体重、性别和皮质醇的Z值可以解释新生儿血清瘦素浓度个体间变异的44%。结论：女性新生儿血清瘦素浓度显著高于男性。胰岛素、IGF-1、睾酮和SHBG并不独立影响瘦素的个体间变异性，当性别、体重Z评分和皮质醇被考虑在内时，其他因素可能参与新生儿性别间循环瘦素浓度的差异。
AIMS: To verify if plasma leptin concentrations of newborns at birth differ significantly between sexes; and to investigate the potential interactions between plasma leptin and growth-regulating hormones at birth.SUBJECTS: 98 healthy newborns (48 male, 50 female) were studied, Leptin, insulin, cortisol, insulin-like growth factor-1 (IGF-1), testosterone, and sex hormone binding globulin (SHBG) concentrations were measured from venous blood collected from the umbilical cord vein immediately after birth.RESULTS: The serum leptin concentration of newborns averaged 8.05(0.5) ng/ml. Females had significantly (P < 0.005) higher serum leptin values than males [9.6(0.8) vs 6.0(0.6) ng/ml]. IGF-1 was significantly (P < 0.05) higher in females than in males [87(4) vs 74(5) mu g/l], whereas SHBG was slightly lower [29(1) vs 33(2) nmol/l]. Insulin, cortisol, and testosterone serum concentrations were not statistically different between the sexes. Among the variables examined, birth weight (expressed as Z-score of weight) and insulin showed the highest degree of relationship with serum leptin in newborns (r = 0.48 and r = 0.31 respectively, P < 0.001). Multiple regression analysis showed that Z-score of birth weight, gender and cortisol were able to account for approximate to 44% of inter-individual variability of serum leptin concentrations in newborns.CONCLUSIONS: Female newborns have significantly higher serum leptin concentrations than males. Insulin, IGF-1, testosterone, and SHBG did not independently affect leptin inter-individual variability when gender, Z-score of body weight, and cortisol were taken into account, Other factors may be involved in the differences in circulating leptin concentrations between the sexes in newborns.