The effects of craniosynostosis on the brain with respect to intracranial pressure.
The effects of craniosynostosis on the brain with respect to intracranial pressure.
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DOI：
10.1016/j.spen.2004.11.001
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发表时间：
2004-12-01
影响因子：
2.7
通讯作者：
Rekate, Harold L
中科院分区：
文献类型：
--
作者：
Bristol, Ruth E;Lekovic, Gregory P;Rekate, Harold L
颅内压和颅骨体积有着千丝万缕的联系。颅缝融合改变了颅骨的体积，而多种形式的颅缝融合使与颅内压的关系更加复杂。与多缝合、颅面综合征或两者兼而有之的患者相比，单缝合的患者发生颅内压升高的可能性较小。在涉及一条以上缝线的患者中，导致颅内压升高的多因素机制包括头颅比例失调和静脉流出道梗阻。对颅内压进行至少24小时的直接监测有助于诊断和决策过程。颅缝闭锁症患者的处理是多样化的，需要有一个长期的随访计划。
Intracranial pressure (ICP) and skull volume are intricately related. Craniosynostosis alters skull volume, and the many forms of craniosynostosis complicate the relationship to ICP even further. Patients with single-suture synostosis are less likely to experience elevated ICP than patients in whom multiple sutures, craniofacial syndromes, or both are involved. Among patients with more than one suture involved, the multifactorial mechanisms underlying elevated ICP include cephalocranial disproportion and venous outflow obstruction. Direct monitoring of ICP for at least 24 hours can aid in the diagnosis and decision making process. The management of craniosynostotic patients is diverse and necessitates a long-term plan for follow-up.