Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells:: Its role in urolithiasis
Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells:: Its role in urolithiasis
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DOI：
10.1159/000045322
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发表时间：
1999-04-01
期刊：
影响因子：
2.5
通讯作者：
Schor, N
中科院分区：
文献类型：
--
作者：
Campos, AH;Schor, N
我们研究了珍珠草水提取物对 Madin-Darby 犬肾细胞 CaOx 晶体内吞模型的体外影响。该提取物对 CaOx 晶体内化表现出强效且有效的非浓度依赖性抑制作用，即使在非常高（病理性）CaOx 浓度下也存在这种反应，并且未检测到 P, niruri L. 诱导的毒性作用。对含有 P. niruri L. 的培养基的生化分析没有为阐明受这种天然产物影响的细胞途径提供任何线索。尽管为了更好地了解 P, niruri L 在尿石症中的作用还需要进一步的研究，但我们的研究结果表明，这种天然产品可能是治疗尿路结石的一种有吸引力的替代品。
We investigated the in vitro effect of an aqueous extract of Phyllanthus niruri L, on a model of CaOx crystal endocytosis by Madin-Darby canine kidney cells. The extract exhibited a potent and effective non-concentration-dependent inhibitory effect on the CaOx crystal internalization This response was present even at very high (pathologic) CaOx concentrations and no P, niruri L.-induced toxic effect could be detected. Biochemical analysis of culture media containing P. niruri L. did not provide any clues for the elucidation of the cellular pathways affected by this natural product. Although further studies are necessary for a better understanding of the role of P, niruri L, in urolithiasis, our findings show that this natural product could be an attractive alternative for the treatment of urinary stones.