C/EBPα induces PU.1 and interacts with AP-1 and NF-κB to regulate myeloid development
C/EBPα induces PU.1 and interacts with AP-1 and NF-κB to regulate myeloid development
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DOI：
10.1016/j.bcmd.2007.06.010
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发表时间：
2007-11-01
影响因子：
2.3
通讯作者：
Friedman, Alan D.
中科院分区：
文献类型：
--
作者：
Friedman, Alan D.
C/EBP α 和 PU.1 是早期骨髓发育的关键调节因子。缺乏 C/EBP α 或 PU.1 的小鼠粒细胞和单核细胞减少。与 C/EBP α 诱导 PU.1 有助于单核细胞谱系规范的模型一致，PU.1 减少的小鼠单核细胞减少但保留粒细胞，C/EBP α 直接激活 PU.1 基因转录，外源 C/EBP α 增加双能骨髓祖细胞的单核细胞谱系定向。除了 C/EBP α 之外，AP-1 蛋白也具有诱导单核细胞成熟的能力。 C/EBP α:c-Jun 或 C/EBP α:c-Fos 亮氨酸拉链异二聚体比 C/EBP α 或 c-Jun 同二聚体或 c-Fos:c-Jun 异二聚体更有效地诱导垄断。 C/EBP 和 NF-kappa B 在炎症反应过程中协同调节众多基因。 C/EBPα碱性区与NF-κB p50相互作用，但不与p65相互作用，以诱导bcl-2，并且这种相互作用可能与骨髓细胞的存活和发育相关。 (C) 2007 Elsevier Inc. 保留所有权利。
C/EBP alpha and PU.1 are key regulators of early myeloid development. Mice lacking C/EBP alpha or PU.1 have reduced granulocytes and monocytes. Consistent with a model in which induction of PU.1 by C/EBP alpha contributes to monocyte lineage specification, mice with reduced PU.1 have diminished monocytes but retain granulocytes, C/EBP alpha directly activates PU.1 gene transcription, and exogenous C/EBP alpha increases monocytic lineage commitment from bipotential myeloid progenitors. In addition to C/EBP alpha, AP-1 proteins also have the capacity to induce Monocytic maturation. C/EBP alpha:c-Jun or C/EBP alpha:c-Fos leucine zipper heterodimers induce monopoiesis more potently than C/EBP alpha or c-Jun homodimers or c-Fos:c-Jun heterodimers. C/EBPs and NF-kappa B cooperatively regulate numerous genes during the inflammatory response. The C/EBPa basic region interacts with NF-kappa B p50, but not p65, to induce bcl-2, and this interaction may be relevant to myeloid cell survival and development. (C) 2007 Elsevier Inc. All rights reserved.