The arterial wall and atherosclerosis.
The arterial wall and atherosclerosis.
复制标题
动脉壁和动脉粥样硬化。
DOI：
10.1146/annurev.me.30.020179.000245
复制
发表时间：
1979
影响因子：
10.5
通讯作者：
R. Ross
中科院分区：
文献类型：
--
作者：
R. Ross
尽管动脉粥样硬化已被认为是西方人死亡的主要原因，但直到最近十年左右，人们才开始了解这种疾病的过程 (1)。该疾病在症状出现之前就已悄然发生。直到对朝鲜战争和越南战争中死亡的美国男性进行研究，证明其在生命的第二个十年内发病率很高时，这种疾病在早年广泛发生才被普遍接受 (2, 3)。动脉粥样硬化的病变主要限于动脉壁的最内层，即内膜。尽管人类病变有多种变体，但人们普遍认为疾病过程由三个事件组成，每个事件都涉及动脉壁细胞。这些包括（a）内膜平滑肌细胞增殖，（b）增殖的平滑肌形成大量结缔组织基质，（c）细胞内和结缔组织中的脂质沉积。它们周围的组织 (4-7)。本文所关注的动脉粥样硬化病变发展的主要生物学现象是内膜平滑肌增殖。由于脂质和钙沉积物的积累，动脉粥样硬化通常被认为是一种退化过程。然而，在没有内膜平滑肌增殖的情况下，可能不会产生具有临床意义的后遗症。流行病学研究已经确定了一系列通常与动脉粥样硬化发病率增加相关的危险因素。如果我们要了解这些危险因素在诱导病变形成中所起的作用，则必须在细胞水平上对其进行解释 (1, 8-13)。
Although atherosclerosis has been recognized as the principal cause of death in Western man, it is only within the last decade or so that the disease process itself has begun to be understood (1). The disease develops insidi ously before the development of symptoms. Its widespread occurrence at an early age was not g�nerally accepted until studies of American males who died in the Korean and Vietnam wars documented its high prevalence within the second decade of life (2, 3). The lesions of atherosclerosis are limited principally to the innermost layer of the artery wall, the intima. Although there are many variants of the lesion in man, there is general acceptance that the disease process consists of three events, each of which involves the cells of the artery wall. These include (a) intimal smooth muscle cell proliferation, (b) formation of large amounts of connective tissue matrix by the proliferated smooth muscle,lmd (c) deposition of lipids both within the cells and in the connec tive. tissues surrounding them (4-7). The principal biological phenomenon in the development of the lesions of atherosclerosis with which this article is concerned is intimal smooth muscle proliferation. Because of the accumulation of lipid and calcium deposits, atherosclerosis has commonly been considered to be a degenera tive process. However, in the absence of intimal smooth muscle prolifera tion there would probably be few sequelae of clinical significance. Epidemiologic research has identified a list of risk factors that are com monly associated with an increased incidence of atherosclerosis. Each of these risk factors must be explained at the cellular level if we are to under stand the role they play in the induction of lesion formation (1, 8-13).
DOI：
10.1002/9780470720974.ch7
发表时间：
1985
期刊：
Ciba Foundation symposium
影响因子：
--
作者：
R. Ross;D. Bowen-Pope;E. Raines
通讯作者：
R. Ross;D. Bowen-Pope;E. Raines