RADIOGRAPHIC OSTEOARTHRITIS OF THE HIP AND BONE-MINERAL DENSITY
RADIOGRAPHIC OSTEOARTHRITIS OF THE HIP AND BONE-MINERAL DENSITY
复制标题
DOI：
10.1002/art.1780380706
复制
发表时间：
1995-07-01
影响因子：
--
通讯作者：
CUMMINGS, SR
中科院分区：
文献类型：
--
作者：
NEVITT, MC;LANE, NE;CUMMINGS, SR
目的：研究65岁及以上参加骨质疏松性骨折研究的白人女性髋部骨关节炎（OA）的x线表现与髋部、脊柱和尾骨的骨密度（BMD）之间的横断面相关性。方法：对4,855名受试者的骨盆x线片进行评估，以确定髋部OA的个体x线特征。骨赘、关节间隙狭窄、软骨下硬化症、囊肿和股骨头畸形，髋关节根据影像学特征的数量以0（无骨关节炎）到4（严重骨关节炎）的综合评分进行分级，所有受试者测量了尾骨骨密度，84%的受试者测量了髋关节和脊柱骨密度。我们使用线性回归来检查骨密度与髋关节骨关节炎的关系，并调整了年龄、体重和其他骨量决定因素。结果，351名女性（7.2%）有轻度（2级），228名女性（4.7%）有中度至重度（3-4级）髋关节骨关节炎的影像学证据。3 - 4年级髋关节OA的女性有更高的年龄调整在股骨颈骨密度和沃德的三角形(9 - 10%;P < 0.0001),转子(4%,P < 0.01),腰椎(8%,P < 0.0001),和远端半径和跟骨(5%,P < 0.0001(为每个比较))与0 - 1年级OA组相比更糟糕的是臀部,海拔在BMD与OA最大的股骨颈的臀部,在双边髋关节OA,女性和女性臀部骨赘。通过调整骨量的决定因素，这些发现基本上没有改变。结论：患有中度至重度髋关节骨性关节炎的老年白人女性比没有髋关节骨性关节炎的女性在髋关节、脊柱和尾骨的骨密度更高，我们的研究结果与骨密度升高在髋关节骨性关节炎发病机制中的作用一致。
Objective, To examine the cross-sectional association between radiographic features of hip osteoarthritis (OA) and bone mineral density (BMD) of the hip, spine, and appendicular skeleton among Caucasian women ages 65 and older who were participating in the Study of Osteoporotic Fractures.Methods, Pelvis radiographs of 4,855 subjects were assessed for individual radiographic features of hip OA: osteophytes, joint space narrowing, subchondral sclerosis, cysts, and femoral head deformity, Hips were graded on a summary scale of 0 (no OA) to 4 (severe OA) based on the number of radiographic features present, Appendicular BMD was measured in all subjects, and hip and spine BMD in 84% of the group, We used linear regression to examine the association of BMD with hip OA, and to adjust for age, weight, and other determinants of bone mass.Results, Three hundred fifty-one women (7.2%) had mild (grade 2) and 228 (4.7%) had moderate to severe (grade 3-4) radiographic evidence of hip OA. Women with grade 3-4 hip OA had a higher age-adjusted BMD at the femoral neck and Ward's triangle (9-10%; P < 0.0001), trochanter (4%; P < 0.01), lumbar spine (8%; P < 0.0001), and distal radius and calcaneus (5%; P < 0.0001 [for each comparison]) compared with those with grade 0-1 OA in the worse hip, Elevations in BMD were greatest in the femoral neck of hips with OA, in women with bilateral hip OA, and in women with hip osteophytes. These findings were essentially unchanged by adjustment for determinants of bone mass.Conclusion, Elderly Caucasian women with moderate to severe radiographic hip OA had higher BMD in the hip, spine, and appendicular skeleton than did women without hip OA, Our findings are consistent with a role of elevated BMD in the pathogenesis of hip OA.