Increased risk of herpes zoster among 108 604 patients with inflammatory bowel disease
Increased risk of herpes zoster among 108 604 patients with inflammatory bowel disease
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DOI：
10.1111/apt.12182
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发表时间：
2013-02-01
影响因子：
7.6
通讯作者：
Kappelman, M. D.
中科院分区：
文献类型：
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作者：
Long, M. D.;Martin, C.;Kappelman, M. D.
背景：服用某些免疫抑制剂的炎症性肠病(IBD)患者患带状疱疹(HZ)的风险增加。目的探讨HZ在IBD发病中的风险及抗肿瘤坏死因子-α(抗肿瘤坏死因子-α)药物对该风险的影响。方法我们利用IMS LifeLink(R)信息资产-健康计划索赔数据库中的管理数据进行了一项回顾性队列和嵌套病例对照研究。在队列中，我们确定了IBD患者
Background Patients with inflammatory bowel disease (IBD) on certain immunosuppressants have increased herpes zoster (HZ) risk. Aim To determine the risk of HZ in IBD and how antitumour necrosis factor-alpha (anti-TNF) agents affect this risk. Methods We performed a retrospective cohort and nested casecontrol study using administrative data from IMS LifeLink (R) Information Assets-Health Plan Claims Database. In the cohort, we identified IBD patients