Optimization of random time domain sampling in multidimensional NMR
Optimization of random time domain sampling in multidimensional NMR
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DOI：
10.1016/j.jmr.2008.02.003
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发表时间：
2008-05-01
影响因子：
2.2
通讯作者：
Kozminski, Wiktor
中科院分区：
文献类型：
--
作者：
Kazimierczuk, Krzysztof;Zawadzka, Anna;Kozminski, Wiktor
关于多维傅立叶变换（MFT）示出并讨论了用于生成不同随机采样方案的规则的详细描述。研究了不同约束随机采样方案对常值信号FT的影响，点扩散函数（PSF），分析考虑伪影的水平和分布。我们发现，泊松盘采样时间表，它提供了一个大的低伪影区域的信号附近，是在NMR实验中的时域非线性采样的情况下的选择方法。我们已经通过应用于C-13，N-15标记的泛素样品获得的3D HNCACB和N-15编辑的NOESY-HSQC光谱来验证新的采样方案。(C)2008年爱思唯尔公司All rights reserved.
The detailed description of rules for generation of different random sampling schemes is shown and discussed with regard to Multidimensional Fourier Transform (MFT). The influence of different constrained random sampling schedules on FT of constant signal, i.e., Point Spread Function (PSF), is analyzed considering artifacts level and distribution. We found that Poisson disk sampling schedule, which provides a large low-artifact area in the signal vicinity, is the method of choice in the case of nonlinear sampling of time domain in NMR experiments. We have verified the new sampling schemes by application to the 3D HNCACB and N-15-edited NOESY-HSQC spectra acquired for C-13, N-15 labeled ubiquitin sample. (C) 2008 Elsevier Inc. All rights reserved.