[Advances in research on immune mechanism of moxibustion for treating tumor].
[Advances in research on immune mechanism of moxibustion for treating tumor].
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DOI：
10.13702/j.1000-0607.1900946
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发表时间：
2020-01-25
期刊：
影响因子：
--
通讯作者：
Xu, Tian Shu
中科院分区：
文献类型：
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作者：
Wu, Yu;Wang, Yu Juan;Xu, Tian Shu
肿瘤的治疗，特别是恶性肿瘤的治疗，是一个世界级的医学难题，至今仍困扰着临床医生和医学家。艾灸疗法在临床应用于肿瘤的治疗已有多年，相关机制的研究也取得了不少成果。本文从患者免疫系统的自我调节和动物模型两方面综述了艾灸治疗肿瘤的研究进展。结果表明，艾灸疗法具有以下抗肿瘤作用：1)调节先天免疫防御功能，增强适应性免疫（通过上调自然杀伤[NK]细胞的活性和巨噬细胞的吞噬功能）；2)刺激细胞免疫(通过提高CD4+/CD8+比值，B淋巴细胞介导的体液免疫（通过调节IgG、IgA、IgM等含量）；3)调节白细胞介素、干扰素、肿瘤坏死因子超家族集落刺激因子、趋化因子生长因子、血管内皮生长因子等细胞因子水平；4)调节许多相关蛋白和基因的表达；5)调节相关激素、神经递质、细胞内激酶信号等，以及其他免疫相关成分。
Treatment of tumors, especially the malignant tumors, is a world-class medical problem and still plagues clinicians and medical scientists a lot nowadays. Moxibustion therapy has been used in the treatment of tumors in clinic practice for many years and the related mechanism researches have achieved a lot of achievements. In the present paper, we reviewed researches on moxibustion treatment for tumor from the self-regulation of the immune system in patients and animal models. Outcomes display that moxibustion therapy has an action in resisting tumors by 1) regulating innate immune defensive function and enhancing adaptive immunity (by up-regulating activities of natural killer [NK] cells, and phagocytic function of macrophages), 2) stimulating cellular immunity (by increasing the ratio of CD4＋/CD8＋， lymphocyte transformation rate, etc.), and B lymphocyte-mediated humoral immunity (via regulating contents of IgG, IgA, IgM, etc.), 3) modulating levels of cytokines as interleukins, interferons, tumor necrosis factor superfamily colony stimulating factor, chemokine growth factor, vascular endothelial growth factor，VEGF, etc., 4) regulating expression of many related proteins and genes, and 5) regulating related hormones, neurotransmitters, intracellular kinases signaling, etc., and other immune-related components.