Cell death in cranial neural crest development
Cell death in cranial neural crest development
复制标题
颅神经嵴发育过程中的细胞死亡
DOI：
10.1007/bf00185617
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Mark Osmond
中科院分区：
文献类型：
--
作者：
P. Jeffs;K. Jaques;Mark Osmond
摘要菱脑神经嵴对许多颅面结构的形成和发育至关重要，它从背侧后脑横向迁移，但不是连续的片状。我们使用活体染料来证明鸟类菱形脑背中线的细胞死亡与神经嵴迁移相关的不连续模式。虽然细胞死亡在第 8 阶段开始于假定中脑的背侧中线，但到第 11 阶段，菱脑中出现了两个不同的细胞死亡区域。吻侧区域位于初级菱形节 RhA1 和菱形节 rh3 上方，而尾侧域出现在耳囊之间的神经中线上，位于 rh5 区域。使用神经嵴标记，我们发现细胞死亡的头侧和尾侧区域与 rh3 和 rh5 神经嵴迁移的缺失相关。因此，特定菱形体背侧区域的节段特异性细胞死亡可能是它们随后未能形成颅神经嵴的原因。
SummaryThe rhombencephalic neural crest, crucial to the patterning and development of many craniofacial structures, migrates laterally from the dorsal hindbrain, but not as a continuous sheet. We have used a vital dye to demonstrate a discontinuous pattern of cell death in the dorsal midline of the avian rhombencephalon associated with the migration of the neural crest. Whilst cell death commences in the dorsal midline of the presumptive mesencephalon at stage 8, two distinct domains of cell death are apparent in the rhombencephalon by stage 11. The rostral domain lies over primary rhombomere RhA1 and rhombomere rh3, while the caudal domain occurs on the neural midline between the otic vesicles, in the region of rh5. Using a marker for the neural crest, we show that the rostral and caudal domains of cell death correlate with the absence of neural crest migration from rh3 and rh5. Thus segment-specific cell death in the dorsal region of particular rhombomeres may account for their subsequent failure to contribute to the cranial neural crest.
影响因子：
10.5
作者：
HILL, RE;JONES, PF;DAVIDSON, DR
通讯作者：
DAVIDSON, DR