MDM2 GENE AMPLIFICATION IN BONE AND SOFT-TISSUE TUMORS - ASSOCIATION WITH TUMOR PROGRESSION IN DIFFERENTIATED ADIPOSE-TISSUE TUMORS
MDM2 GENE AMPLIFICATION IN BONE AND SOFT-TISSUE TUMORS - ASSOCIATION WITH TUMOR PROGRESSION IN DIFFERENTIATED ADIPOSE-TISSUE TUMORS
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DOI：
10.1002/ijc.2910640511
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发表时间：
1995-10-20
影响因子：
6.4
通讯作者：
SASAKI, MS
中科院分区：
文献类型：
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作者：
NAKAYAMA, T;TOGUCHIDA, J;SASAKI, MS
我们研究了 107 例骨和软组织肉瘤和 8 例脂肪瘤，以扩增 MDM2 基因。该基因在 67 个骨肉瘤中的 3 个、20 个恶性纤维组织细胞瘤中的 3 个、20 个脂肪肉瘤中的 4 个以及 8 个脂肪瘤中的 4 个中扩增。扩增与 mRNA 的过度表达相关。在骨肉瘤中，与之前的发现相反，所有扩增均在原发病变中观察到。在脂肪肉瘤中，扩增仅在分化良好的肿瘤中以高频率出现（4/5），但在其他亚型中则没有出现（0/15）。此外，MDM2 扩增也常见于深部肌内或肌间脂肪瘤 (4/5)。因此，表明MDM2扩增在分化的脂肪组织肿瘤的发展中发挥重要作用。三种具有MDM2扩增的高分化脂肪肉瘤与高级别去分化肉瘤共存，其中也观察到MDM2扩增。有趣的是，在其中 2 个病例中，扩增等级与组织学等级相关，表明 MDM2 过表达在肿瘤进展中发挥重要作用。 (C) 1995 Wiley-Liss, Inc.
We have studied 107 bone and soft-tissue sarcomas and 8 lipomas for amplification of the MDM2 gene. This gene was amplified in 3 out of 67 osteosarcomas, 3 out of 20 malignant fibrous histiocytomas, 4 out of 20 liposarcomas, and 4 out of 8 lipomas. The amplification was associated with overexpression of mRNA. In osteosarcomas, contrary to previous findings, all amplifications were observed in primary lesions. In liposarcomas, the amplification was seen exclusively in well-differentiated tumors with high frequency (4/5) but not in other subtypes (0/15). In addition, MDM2 amplification was also frequently found in deep-seated intra- or intermuscular lipomas (4/5). Hence, it is suggested that MDM2 amplification plays a significant role in the development of differentiated adipose-tissue tumors. Three well-differentiated liposarcomas with MDM2 amplification coexisted with high-grade dedifferentiated sarcomas, in which MDM2 amplification was also observed. Interestingly, in 2 of these cases, the grades of amplification correlated with the histological grades, indicating an important role of MDM2 overexpression in tumor progression. (C) 1995 Wiley-Liss, Inc.