Effects of delta-9-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combinations, on luteinizing hormone and prolactin release and on hypothalamic neurotransmitters in the male rat.
Effects of delta-9-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combinations, on luteinizing hormone and prolactin release and on hypothalamic neurotransmitters in the male rat.
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δ-9-四氢大麻酚、大麻酚和大麻二酚单独和组合对雄性大鼠黄体生成素和催乳素释放以及下丘脑神经递质的影响。
DOI：
10.1159/000125604
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发表时间：
1990
影响因子：
4.1
通讯作者：
Bartke,A
中科院分区：
文献类型：
--
作者：
Murphy,LL;Steger,RW;Smith,MS;Bartke,A
在成年雄性大鼠中检查了低口服剂量的Δ9-四氢大麻酚（THC）、大麻酚（CBN）和大麻二酚（CBD）单独或组合施用对LH和催乳素（PRL）分泌以及对下丘脑去甲肾上腺素（NE）、多巴胺（DA）和5-羟色胺（5-HI）动力学的急性作用。给予0.5 mgTHC/kg体重后60分钟以及给予THC + CBN或THC + CBD后30、60和120分钟，血浆LH水平显着降低。血浆PRL对大麻素治疗没有反应。NE在正中隆起（ME）和内侧基底下丘脑（MBH）的营业额显着影响所有大麻素治疗。NE转换的完全抑制发生在THC后30分钟和THC + CBN后120分钟的ME和THC + CBD后120分钟的MBH。大麻素没有显着影响DA营业额在MBH或NE，DA，5-HT或5-羟基吲哚-3-乙酸的含量在ME或MBH。这些数据表明，用低剂量的THC治疗成年雄性大鼠抑制LH分泌，CBN和CBD增强THC的这种作用。虽然大麻素抑制LH释放的机制不能从这些实验中得到肯定，但结果表明，下丘脑去甲肾上腺素能活性的改变可能与这种效应有关。
The acute effects of low oral doses of Δ9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) administered alone or in combinations on LH and prolactin (PRL) secretion and on hypothalamic norepinephrine (NE), dopamine (DA) and serotonin (5-HI) dynamics were examined in adult male rats. Plasma LH levels were significantly reduced 60 min after administration of 0.5 mgTHC/kg body weight and 30, 60 and 120 min after administration of THC + CBN or THC + CBD. There were no changes in plasma PRL in response to cannabinoid treatments. The turnover of NE in both the median eminence (ME) and medial basal hypothalamus (MBH) was dramatically affected by all the cannabinoid treatments. Complete suppression of NE turnover occurred 30 min post-THC and 120 min post-THC + CBN in the ME and 120 min post-THC + CBD in the MBH. Cannabinoids did not significantly affect DA turnover in the MBH or the content of NE, DA, 5-HT or 5-hydroxyindole-3-acetic acid in either the ME or MBH. These data demonstrate that treatment of adult male rats with a low dose of THC suppresses LH secretion and that CBN and CBD potentiate this action of THC. Although the mechanisms responsible for the inhibition of LH release by cannabinoids cannot be positively identified from these experiments, the results suggest that alterations in hypothalamic noradrenergic activity may be involved in this effect.