Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells
Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells
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DOI：
10.1016/j.immuni.2005.06.011
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发表时间：
2005-08-01
期刊：
影响因子：
32.4
通讯作者：
Karasuyama, H
中科院分区：
文献类型：
--
作者：
Mukai, K;Matsuoka, K;Karasuyama, H
经常观察到嗜碱性粒细胞募集到过敏性炎症部位。然而，没有确切的证据表明嗜碱性粒细胞在慢性变态反应性疾病的发病机制中起关键作用。在这里，我们表明，嗜碱性粒细胞是负责IgE介导的慢性过敏性炎症的发展独立的T细胞和肥大细胞。单次皮下注射多价抗原不仅引起立即和晚期耳肿胀，但也迟发性耳肿胀与大量嗜酸性粒细胞浸润的抗原特异性IgE致敏的小鼠。肥大细胞在耳肿胀的即刻和晚期是必不可少的，但在延迟性耳肿胀中是不可或缺的。T细胞也为后者所抑制。将表达Fc ε RI的嗜碱性粒细胞转移到Fc ε RI缺陷小鼠中，恢复了迟发型过敏性炎症的发生。这些发现表明，嗜碱性粒细胞通过抗原、IgE和Fc β RI相互作用诱导慢性过敏性炎症的新机制。
The recruitment of basophils into the sites of allergic inflammation is often observed. However, no definitive evidence has been provided that basophils are crucially involved in the pathogenesis of chronic allergic disorders. Here, we show that basophils are responsible for the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. A single subcutaneous injection of multivalent antigens elicited not only immediate and late-phase ear swelling but also delayed-onset ear swelling with massive eosinophil infiltration in mice sensitized with antigen-specific IgE. Mast cells were essential for the immediate and late-phase ear swelling but dispensable for the delayed one. T cells were also dispensable for the latter. Transfer of FC epsilon RI-expressing basophils into Fc epsilon RI-deficient mice restored the development of the delayed-onset allergic inflammation. These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the interaction of antigen, IgE, and Fc epsilon RI.