Alteration of liposome disposition in vivo by bilayer situated carbohydrates.
Alteration of liposome disposition in vivo by bilayer situated carbohydrates.
复制标题
双层碳水化合物改变体内脂质体的分布。
DOI：
10.1016/0006-291x(83)91271-8
复制
发表时间：
1983
影响因子：
3.1
通讯作者：
Mayhew,E
中科院分区：
文献类型：
--
作者：
SzokaJr,FC;Mayhew,E
在小单层囊泡中以9%的摩尔比包含乳糖苷或二甘露糖基甘油二酯使小鼠肝脏中出现的静脉注射剂量的分数增加了2 - 3倍。对于含有乳糖苷的脂质体，从血浆中清除的半衰期为1.2小时，而对于具有相似大小、电荷和组成但缺乏糖脂的脂质体为5.5小时。通过同时注射去唾液酸核糖核酸，可以显著减少肝脏对含乳糖苷脂脂质体的摄取，但不能消除。
The inclusion of either lactosylcerebroside or dimannosyldiglyceride at a 9% molar ratio in small unilamellar vesicles increased by two-three fold the fraction of the I.V. dose that appeared in mouse liver. For lactosylcerebroside containing liposomes, the half-time for clearance from plasma was 1.2 hours compared to 5.5 hours for liposomes of similar size, charge, and composition but lacking the glycolipid. Uptake of the lactosylcerebroside containing liposomes by the liver could be significantly reduced but not eliminated by the simultaneous injection of asialoorosomucid.